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Sie sind hier: Startseite AK Müller Publikationen

Publikationen

2016

  • Enas M. Malik, Mahmoud Rashed, Lukas Wingen, Younis Baqi, Christa E. Müller;
    Ullmann reactions of 1-amino-4-bromoanthraquinones bearing various 2-substituents furinishing novel dyes.
    Dyes and Pigments 2016, 131, 33-40
  • Kenneth A. Jacobson, Christa E. Müller;
    Medicinal chemistry of adenosine, P2Y and P2X receptors.
    Neuropharmacol. 2016, 104, 31-49. 
  • Cornelius Hess, Clara T. Schoeder, Thanigaimalai Pillaiyar, Burkhard Madea, Christa E. Müller;
    Pharmacological evaluation of synthesis cannabinoids identified as constituents of spice.
    Forensic Toxicol. 2016, 34, 329-343. 
  • Sang-Yong Lee, Arianna Perotti, Steven De Jonghe, Piet Herdewijn, Theodor Hanck, Christa E. Müller;
    Thiazolo[3,2-a]benzimidazol-3(2H)-one derivatives: structure-activity relationships of selective nucleotide pyrophosphatase/phosphodiesterase1 (NPP1) Inhibitors.
    Bioorg. Med. Chem.2016, 24, 3157-3165.
  • Elisabetta De Filippo, Vigneshwaran Namasivayam, Lukas Zappe, Ali El-Tayeb, Anke C. Schiedel, and Christa E. Müller;
    Role of extracellular cysteine residues in the adenosine A2A receptor.
    Purinergic Signal. 2016, 12, 313-329. 
  • Paul A. Mann, Anna Müller, Kerstin A. Wolff, Thierry Fischmann, Hao Wang, Patricia Reed, Yan Hou, Wenjin Li, Christa E. Müller, Jianying Xiao, Nicholas Murgolo, Xinwei Sher, Todd Mayhood, Payal R. Sheth, Asra Mirza, Marc Labroli, Li Xiao, Mark McCoy, Charles J. Gill, Mariana G. Pinho, Tanja Schneider, Terry Romer;
    Chemical genetic analysis and functional characterization of staphylococcal wall teichoic acid 2-epimerases reveals unconventional antibiotic drug Targets.
    PLoS Pathog. 2016, 12(5), e1005585. 
  • Samantha J. Podurgiel, Tiahna Spencer, Rotem Kovner, Younis Baqi, Christa E. Müller, Merce Correa, John D. Salamone;
    Induction of oral tremor in mice by the acetylcholinesterase inhibitor galantamine: reversal with adenosine A2A antagonism.
    Pharmacol. Biochem. Behav. 2016, 140, 62-67.
  • Cyril Laurent, Sylvie Burnouf, B. Ferry, Vânia L. Batalha, Joana E. Coelho, Younis Baqi, Enas Malik, Elodie Marciniak, S. Parrot, Ann Van der Jeugd, E. Faivre, V. Flaten, Catherine Ledent, Rudi D’Hooge, Nicolas Sergeant, Malika Hamdane, Sandrine Humez, Christa E. Müller, Luisa V. Lopes, Luc Buée, David Blum;
    A2A adenosine receptor deletion is protective in a mouse model of tauopathy.
    Mol. Psychiatry 2016, 21, 97-107. 
  • Vânia L. Batalha, Diana G. Ferreira, Joana E. Coelho, Jorge S. Valadas, Rui Gomes, Mariana Temido-Ferreira, Tatiana Shmidt, Younis Baqi, Luc Buée, Christa E. Müller, Malika Hamdane, Tiago F. Outeiro, Michael Bader, Sebastiaan H. Meijsing, Ghazaleh Sadri-Vakili, David Blum, Luisa V. Lopes;
    The caffeine-binding adenosine A2A receptor induces age-like HPA-axis dysfunction by targeting glucocorticoid receptor function.
    Nat. Sci. Rep. 2016, 6: 31493, doi: 10.1038/srep313493.
  • Amelie Fiene, Younis Baqi, Enas M. Malik, Patrice Newton, Wenjin Li, Sangyong Lee, Elizabeth L. Hartland, Christa E. Müller;
    Inhibitors for the bacterial Ectonucleotidase Lp1NTPDase from Legionella pneumophila.
    Bioorg. Med. Chem. 2016, 24, 4363-4371. 
  • Caroline Flegel, Felix Vogel, Adrian Hofreuter, Sebastian Wojcik, Clara Schoeder, Katarzyna Kieć-Kononowicz, Norbert H. Brockmeyer, Christa E. Müller, Christian Becker, Janine Altmüller, Hanns Hatt, Günter Gisselmann;
    Characterization of non-olfactory GPCRs in human sperm with a foucs on GPR18.
    Nat. Sci. Rep. 2016, 6: 32255, doi: 10.1038/srep32255.
  • Laura López-Cruz, Noemi Dan-Miguel, Pilar Bayarri, Younis Baqi, Christa E. Müller, John D. Salamone, Mercé Correa;
    Ethanol and caffeine effects on social interaction and recoginition in mice; involvement of adenosine A2A and A1 Receptors.
    Front. Behav. Neurosci. 2016, 10, 1-15.
  • Andreas Brunschweiger, Pierre Koch, Miriam Schlenk, Muhammad Rafehi, Hamid Radjainia, Petra Küppers, Sonja Hinz, Felipe Pineda, Michael Wiese, Jörg Hockemeyer, Jag Heer, Frédéric Denonne, Christa E. Müller;
    8-Substituted 1,3-dimethyltetrahydropyrazino[2,1-f]purinediones: Water-soluble adenosine receptor antagonists and monoamine oxidase B inhibitors.
    Bioorg. Med. Chem. 2016, 24, 5462-5480. 
  • Jin-Hee Park, Darren R. Williams, Ji-Hyung Lee, So-Deok Lee, Je-Heon Lee, Hyojin Ko, Ga-Eun Lee, Sujin Kim, Jeong-Min Lee, Aliaa Abdelrahman, Christa E. Müller, Da-Woon Jung, Yong-Chul Kim;
    Potent suppressive effects of 1-piperidinylimidaole based novel P2X7 receptor antagonists on cancer cell migration and Invasion.
    J. Med. Chem. 2016, 59, 7410-7430.
  • Joachim C. Burbiel, Wadih Ghattas, Petra Küppers, Meryem Köse, Svenja Lacher, Anna-Maria Herzner, Rajan Subramanian Kombu, Raghuram Rao Akkinepally, Jörg Hockemeyer, Christa E. Müller;
    2-Amino[1,2,4]triazolo[1,5-c]quinazolines and derived novel heterocycles: Synthesis and struct
    re-activity relationships of potent adenosine receptor antagonists.
    ChemMedChem 2016, 11, 2272-2286.
  • Enas M. Malik, Christa E. Müller;
    Anthraquinones as Pharmacological Tools and Drugs.
    Med. Res. Rev. 2016, 36, 705-748.

 2015

  • Sanjay Bhattarai, Marianne Freundlieb, Jan Pippel, Anne Meyer, Aliaa Abdelrahman, Amelie Fiene, Sang-Yong Lee, Herbert Zimmerman, Gennady G. Yegutkin, Norbert Sträter, Ali El-Tayeb, Christa E. Müller;
    Methylene-ADP (AOPCP) derivatives and analogues: development of potent and selective ecto-5'-nucleotidase (CD73) inhibitors.
    J. Med. Chem. 2015, 58, 6248-6263.
  • Enas M. Malik, Younis Baqi, Christa E. Müller;
    Syntheses of 2-substituted 1-amino-4-bromoanthraquinones (bromaminic acid analogues) – precursors for dyes and drugs.
    Beilstein J. Org. Chem. 2015, 11, 2326-2333.
  • Bellamkonda K. Kishore, Noel G. Carlosin, Carolyn M. Ecelbarger, D. E. Kohan, Christa E. Müller, R. D. Nelson, János Peti-Peterdi, Yue Zhang;
    Targeting renal purinergic signalling for the treatment of lithium-induced nephrogenic diabetes insipitus.
    Acta Physiol. 2015, 214, 176-188.
  • Silvia Paoletta, Davide Sabbadin, Ivar von Kügelgen, Sonja Hinz, Vsevolod Katritch, Kristina Hoffmann, Aliaa Abdelrahman, Jens Straßburger, Younis Baqi, Qiang Zhao, Raymond C. Stevens, Stefano Moro, Christa E. Müller, Kenneth A. Jacobson;
    Modeling ligand recognition at the P2Y12 receptor in light of X-ray structural information.
    J. Comput.-Aided Mol. Des. 2015, 29, 737-756.
  • Marie-Therese Fuzzati-Armentero, Silvia Cerri, Giovanna Levandis, Giulia Ambrosi, Elena Montepeloso, Ginafilippg Antoninetti, Fabio Blandini, Younis Baqi, Christa E. Müller, Rosario Volpini, Giulia Costa, Nicola Simola, Annalisa Pinna;
    Dual target strategy: combining distinct non-dopaminergic Treatments reduces neuronal cell loss and synergistically modulates L-DOPA-induced rotational behavior in a rodent model of Parkinson's disease.
    J. Neurochem. 2015, 134, 740-747. 
  • Mamona Nazir, Henrik Harms, Irene Loef, Stefan Kerhaus, Fayrouz El Maddah, Idris Arslan, Viktor Rempel, Christa E. Müller, Gabriele M. König;
    GPR18 inhibiting amauromine and the novel triterpene glycoside auxarthonoside from the sponge-derived fungus Auxarthron reticulatum.
    Planta Med. 2015, 81, 1141-1145.

  • Jasmin Wiemann, Tzu-Ruei Yang, Philipp N. Sander, Marion Schneider, Marianne Engeser, Stephanie Kath-Schorr, Christa E. Müller, P. Martin Sander;
    The blue-green eggs of dinosaurs: How fossil metabolites provide insights into the evolution of bird reproduction.
    PeerJ PrePrints 2015, 3:e1323; https://dx.doi.org/10.7278/peerj.preprints.1080.
  • Ramona Schrage, Anna-Lena Schmitz, Evelyn Gaffal, Suvi Annala, Stefan Kehraus, Daniela Wenzel, Katrin M. Büllesbach, Tobias Bald, Asuka Inoue, Yuji Shinjo, Ségolène Galandrin, Naveen Shridhar, Michael Hesse, Manuel Grundmann, Nicole Merten, Thomas H. Charpentier, Matthew Martz, Adrian J. Butcher, Tanja Slodczyk, Sylvain Armando, Maike Effern, Yoon Namkung, Laura Jenkins, Velten Horn, Anne Stößel, Harald Dargatz, Daniel Tietze, Diana Imhof, Céline Galés, Christel Drewke, Christa E. Müller, Michael Hölzel, Graeme Milligan, Andrew B. Tobin, Jesús Gomeza, Henrik G. Dohlman, John Sondek, T. Kendall Harden, Michel Bouvier, Stéphane A. Laporte, Junken Aoki, Bernd K. Fleischmann, Klaus Mohr, Gabriele M. König, Thomas Tüting, Evi Kostenis;
    The experimental power of FR900359 to study Gq-regulated biological processes.
    Nat. Commun. 2015, 6: 10156, doi:10.1038/ncomms10156.

 

  • Amelie Fiene, Younis Baqi, Joanna Lecka, Jean Sévigny, Christa E. Müller;
    Fluorescence polarization immunoassays for monitoring nucleoside triphosphatediphosphohydrolase (NTPDase) activity.
    Analyst 2015, 140, 140-148.
  • Sangyong Lee, Amelie Fiene, Wenjin Li, Theodor Hanck, Konstantin A. Brylev, Vladimir E. Fedorov, Joanna Lecka, Ali Haider, Hans-Jürgen Pietzsch, Herbert Zimmermann, Jean Sévigny, Ulrich Kortz, Holger Stephan, Christa E. Müller;
    Polyoxometalates - Potent and selective ecto-nucleotidase inhibitors.
    Biochem. Pharmacol. 2015, 93, 171–181.
  • Christa E. Müller;
    Medicinal chemistry of P2X receptors: Allosteric modulators.
    Curr. Med. Chem. 2015, 22, 929-941.
  • Ramasri Sathanoori, Federica Rosi, B. J. Gu, James S. Wiley, Christa E. Müller, Björn Olde, David Erlinge;
    Shear stress modulates endothelial KLF2 through activiation of P2X4.
    Purinergic Signal. 2015, 11, 139-153.
  • Samantha E. Yohn, Christian Thompson, Patrick A. Randall, Christie A. Lee, Christa E. Müller, Younis Baqi, Mercè Correa, John D. Salamone;
    The VMAT-2 inhibitor tetrabenazine alters effort-related decision making as measured by the T-maze barrier choice task: reversal with the adenosine A2A antagonist MSX-3 and the catecholamine uptake blocker bupropion.
    Psychopharmacol. 2015, 232,
    1313-1323.
  • Manuella P. Kaster, Nuno J. Machado, Henrique B. Silva, Ana Nunes, Ana Paula Ardais, Magda Santana, Younis Baqi, Christa E. Müller, Ana Lúcia S. Rodrigues, Lisiane O. Porciúncula, Jiang-Fan Chen, Ângelo R. Tomé, Paula M. Agostinho, Paula M. Canas, Rodrigo A. Cunha;
    Caffeine acts through neuronal adenosine A2A receptors to prevent mood and memory dysfunction triggered by chronic stress.
    Proc. Natl. Acad. Sci. USA 2015, 112, 7833-7838.
  • Wei Li, Henrique B. Silva, Joana Real, Yu-Mei Wang, Daniel Rial, Ping Li, Marie-Pierce Payen, Yauanguo Zhou, Christa E. Müller, Angelo R. Tomé, Rodrigo A. Cunha, Jiang-Fan Chen;
    Inactivation of adenosine A2A receptors reverses working memory deficits at early stages of Huntington’s disease models.
    Neurobiol. Disease 2015, 79, 70-80.
  • Wenjin Li, Isabell Zech, Volkmar Gieselmann, Christa E. Müller;
    A capillary electrophoresis method with dynamic pH junction stacking for the monitoring of cerebroside sulfotransferase.
    J. Chromatogr. A 2015, 1407, 222-227.
  • Dominik Thimm, Anke C. Schiedel, János Peti-Peterdi, Bellamkonda K. Kishore, Christa E. Müller;
    The nucleobase adenine as a signalling molecule in the kidney.
    Acta Physiol. 2015, 213, 808-818.
  • Yue Zhang, Janos Peti-Peterdi, Christa E. Müller, Noel G. Carlson, Younis Baqi, David L. Strasburg, Kristina M. Heiney, Karie Villaneuva, Donald E. Kohan, Bellamkonda K. Kishore;
    P2Y12 receptor localizes in the renal collecting duct and its blockade augments arginine vasopressin action and alleviates nephrogenic diabetes insipidus.
    J. Am. Soc. Nephrol. 2015, 26, 2978-2987.
  • Mohamad Wessam Alnouri, Stephan Jepards, Alessandro Casari, Anke C. Schiedel, Sonja Hinz, Christa E. Müller;
    Selectivity is species-dependent: Characterization of standard agonists and antagonists at human, rat, and mouse adenosine receptors.
    Puringeric Sigal. 2015, 11, 389-407. 

2014

  • Fabian Heisig, Sabrina Gollos, Sven J. Freudenthal, Ali El-Tayeb, Jamshed Iqbal, Christa E. Müller;
    Synthesis of BODIPY derivatives substituted with various bioconjugatable linker groups: A construction kit for fluorescent labeling of receptor ligands.
    J. Fluoresc. 2014, 24, 213-230.
  • Eric E. Nunes, Patrick A. Randall, Alexavier Estrada, Brian Epling, Evan H. Hart, Christie A. Lee, Younis Baqi, Christa E. Müller, Mercé Correa, John D. Salamone;
    Effort-related motivational effects of the pro-inflammatory cytokine interleukin 1-beta: studies with the concurrent fixed ratio 5/ chow feeding choice task.
    Psychopharmacol. 2014, 231, 726-737. 
  • Maoqun Tian, Aliaa Abdelrahman, Stephanie Weinhausen, Sonja Hinz, Stefanie Weyer, Stefan Dosa, Ali El-Tayeb, Christa E. Müller;
    Carbamazepine derivatives with P2X4 receptor-blocking activity.
    Bioorg. Med. Chem. 2014, 22, 1077-1088.
  • Younis Baqi, Samer Alshaibani, Kirsten Ritter, Aliaa Abdelrahman, Andreas Spinrath, Evi Kostenis, Christa E. Müller;
    Improved synthesis of 4-/6-substituted 2-carboxy-1H-indole-3-propionic acid derivatives and structure-activity relationships as GPR17 agonists.
    Med. Chem. Commun. 2014, 5, 86-92.
  • L-DOPA-treatment in primates disrupts the expression of A2A adenosine-CB1 cannabinoid-D2 dopamine receptor heteromers in the caudate nucleus.
    Neuropharmacol. 2014, 79, 90-100.
  • Matthias Mertens, Sonja Hinz, Christa E. Müller, Michael Gütschow;
    Alkynyl–coumarinyl ethers as MAO-B inhibitors.
    Bioorg. Med. Chem. 2014, 22, 1916-1928.
  • Sang-Yong Lee, Christa E. Müller;
    Large-volume sample stacking with polarity switching for monitoring of nucleotide pyrophosphatase/phosphodiesterase 1 (NPP1) reactions by capillary electrophoresis.
    Electrophoresis 2014,
    35, 855–863.
  • Viktor Rempel, Kerstin Atzler, Andrea Behrenswerth, Tadeusz Karcz, Clara Schoeder, Sonja Hinz, Maria Kaleta, Dominik Thimm, Katarzyna Kieć-Kononowicz, Christa E. Müller;
    Bicyclic imidazole-4-one derivatives: a new class of antagonists for the orphan G protein-coupled receptors GPR18 und GPR55.
    Med. Chem. Commun. 2014, 5, 632-649.
  • Meryem Köse, Kirsten Ritter, Katharina Thiemke, Michel Gillard, Evi Kostenis, Christa E. Müller;
    Development of [3H]2-carboxy-4,6-dichloro-1H-indole-3-propionic acid ([3H]PSB-12150): a useful tool for studying GPR17.
    ACS Med. Chem. Lett. 2014, 5, 326-330.
  • Kaihua Zhang, Jin Zhang, Zhan-Guo Gao, Dandan Zhang, Lan Zhu, GyeWon Han, Steven M. Moss, Silvia Paoletta, Evgeny Kiselev, Weizhen Lu, Gustavo Fenalti, Wenru Zhang, Christa E. Müller, Huaiyu Yang, Hualiang Jiang, Vadim Cherezov, Vsevolod Katritch, Kenneth A. Jacobson, Raymond C. Stevens, Beili Wu, Qiang Zhao;
    Structure of the human P2Y12 receptor in complex with an antithrombotic drug.
    Nature 2014, 509, 115-118.
  • Jin Zhang, Kaihua Zhang, Zhan-Guo Gao, Silvia Paoletta, Dandan Zhang, Gye Won Han, Tingting Li, Limin Ma, Wenru Zhang, Christa E. Müller, Huaiyu Yang, Hualiang Jiang, Vadim Cherezov, Vsevolod Katritch, Kenneth A. Jacobson, Raymond C. Stevens, Beili Wu, Qiang Zhao;
    Agonist-bound structure of the human P2Y12 receptor.
    Nature 2014, 509, 119-122.
  • Henrik Harms, Viktor Rempel, Stefan Kehraus, Marcel Kaiser, Peter Hufendiek, Christa E. Müller, Gabriele M. König;
    Indoloditerpenes from a marine-derived fungal strain of Dichotomomyces cejpii with antagonistic activity at GPCR18 and cannabinoid receptors.
    J. Nat. Prod. 2014, 77, 673-677.
  • André Jerónimo-Santos, Vânia L. Batalha, Christa E. Müller, Younis Baqi, Ana Maria Sebastião, Luisa V. Lopes, Maria José Diógenes;
    Impact of in vivo chronic blockade of adenosine A2A receptors on the BDNF-mediated facilitation of LTP.
    Neuropharmacol. 2014, 83, 99-106.
  • Gergely Horváth, Flóra Gölöncsér, Cecilia Csölle, Kornél Király, Rómeó D. Andó, Mária Baranyi, Bence Koványi, Zoltán Máté, Kristina Hoffmann, Irina Algaier, Younis Baqi, Christa E. Müller, Ivar Von Kügelgen, Beáta Sperlágh;
    Central P2Y12 receptor blockade alleviates inflammatory and neuropathic pain and cytokine production in rodents.
    Neurobiol. Dis. 2014, 70, 162-178.
  • Patrick A. Randall, Christie A. Lee, Eric J. Nunes, Samantha E. Yohn, Victoria Nowak, Bilal Khan, Priya Shah, Saagar Pandit, V. Kiran Vemuri, Alex Makriyannis, Younis Baqi, Christa E. Müller, Merce Correa, John D. Salamone;
    The VMAT-2 inhibitor tetrabenazine affects effort-related decision making in a progressive ratio/chow feeding choice task: reversal with antidepressant drugs.
    PLoS one 2014, e99320.
  • Cyril Laurent, Sabiha Eddarkaoui, Maxime Derisbourg, Antoine Leboucher, Dominique Demeyer, Sébastien Carrier, Marion Schneider, Malika Hamdane, Christa E. Müller, Luc Buée, David Blum;
    Beneficial effects of caffeine in a transgenic model of Alzheimer’s disease-like tau pathology.
    Neurobiol. Aging 2014, 35, 2079-2090.
  • Sonja Hinz, Svenja K. Lacher, Benjamin F. Seibt, Christa E. Müller;
    BAY60-6583 acts as a partial agonist at adenosine A2B receptors.
    J. Pharmacol. Exp. Ther. 2014, 349, 427–436.
  • Karin Önnheim, Karin Christenson, Michael Gabla, Joachim C. Burbiel, Christa E. Müller, Tudor I. Opreaa, Johan Bylund, Claes Dahlgren, Huamei Forsman;
    A novel receptor cross-talk between the ATP receptor P2Y2 and formyl peptide receptors reactivates desensitized neutrophils to produce superoxide.
    Exp. Cell Res. 2014, 323, 209-217.
  • Matthias Zebisch, Younis Baqi, Petra Schäfer, Christa E. Müller, Norbert Sträter;
    Crystal structure of NTPDase2 in complex with the sulfoanthraquinone inhibitor PSB-071.
    J. Struct. Biol. 2014, 185, 336-341.
  • Andreas Brunschweiger, Pierre Koch, Miriam Schlenk, Felipe Pineda, Petra Küppers, Sonja Hinz, Meryem Köse, Stefan Ullrich, Jörg Hockemeyer, Michael Wiese, Jag Heer, Christa E. Müller;
    8-Benzyltetrahydropyrazino[2,1-f]purinediones: water-soluble tricyclic xanthine derivatives as multitarget drugs for neurodegenerative diseases.
    ChemMedChem 2014, 9,
    1704–1724.
  • Nikolay T. Tzvetkov, Sonja Hinz, Petra Küppers, Marcus Gastreich, Christa E. Müller;
    Indazole- and indole-5-carboxamides: selective and reversible monoamine oxidase B inhibitors with subnanomolar potency.
    J. Med. Chem. 2014,
    57, 6679−6703.
  • Silvia Cerri, Giovanna Levandis, Giulia Ambrosi, Elena Montepeloso, Gian Filippo Antoninetti, Rafael Franco, José Luis Lanciego, Younis Baqi, Christa E. Müller, Annalisa Pinna, Fabio Blandini, Marie Therese Armentero;
    Neuroprotective potential of adenosine A2A and cannabinoid CB1 receptor antagonists in an animal model of Parkinson disease.
    J. Neuropath. Exp. Neurol. 2014, 73, 414-424.
  • Wenjin Li, Hannah Ulm, Marvin Rausch, Xue Li, Katie O’Riordan, Jean C. Lee, Tanja Schneider, Christa E. Müller;
    Analysis of the Staphylococcus aureus capsule biosynthesis pathway in vitro: Characterization of the UDP-GlcNAc C6 dehydratases CapD and CapE and identification of enzyme inhibitors.
    Int. J. Med. Microbiol. 2014, 304, 958-969.
  • Alexander Fuchs, Roland Baur, Clara Schoeder, Erwin Sigel, Christa E. Müller;
    Structural analogues of the natural products magnolol and honokiol as potent allosteric potentiators of GABAA receptors.
    Bioorg. Med. Chem. 2014, 22, 6908-6917.
  • Kristina Hoffmann, Dominique A. Lutz, Jens Straßburger, Younis Baqi, Christa E. Müller, Ivar von Kügelgen;
    Competitive mode and site of interaction of ticagrelor at the human platelet P2Y12 receptor.
    J. Thromb. Haemost. 2014, 12, 1898-1905.
  • Holger Stephan, Martin Walther, Silke Fähnemann, Paola Ceroni, Jennifer K. Molloy, Giacomo Bergamini, Fabian Heisig, Christa E. Müller, Werner Kraus, Peter Comba;
    Bispidines for Dual Imaging.
    Chem. Eur. J. 2014, 20, 17011-17018.
  • Christa E. Müller, Anke C. Schiedel, Herbert Zimmermann;
    Purines 2014: Nucleotides, nucleosides and nucleobases – international conference on signalling, drugs and targets.
    Purinergic Signal. 2014, 10, 651-656.
  • Miriam C. Peeters, Qilan Li, Rachel Elands, Gerard J.P. van Westen, Eelke B. Lenselink, Christa E. Müller, Adriaan P. IJzerman;
    Domains for activation and inactivation in G protein-coupled receptors – A mutational analysis of constitutive activity of the adenosine A2B receptor.
    Biochem. Pharmacol. 2014, 92, 348-357.
  • Yassine Sassi, Andrea Ahles, Dong-Jiunn Jeffery Truong, Younis Baqi, Sang-Yong Lee, Britta Husse, Jean-Sébastien Hulot, Ariana Foinquinos, Thomas Thum, Christa E. Müller, Andreas Dendorfer, Bernhard Laggerbauer, Stefan Engelhardt;
    Cardiac myocyte–secreted cAMP exerts paracrine action via adenosine receptor activation.
    J. Clin. Invest. 2014, 124, 5385-5397.
  • Lei Chang, Sang-Yong Lee, Piotr Leonczak, Jef Rozenski, Steven De Jonghe, Theodor Hanck, Christa E. Müller, Piet Herdewijn;
    Imidazopyridine- and purine-thioacetamide derivatives: potent inhibitors of nucleotide pyrophosphatase/phosphodiesterase 1 (NPP1).
    J. Med. Chem. 2014, 57, 10080-10100.
  • Thorsten Gnad, Saskia Scheibler, Ivar von Kügelgen, Camilla Scheele, Ana Kilić, Anja Glöde, Linda S. Hoffmann, Laia Reverte-Salisa, Philipp Horn, Samet Mutlu, Ali El-Tayeb, Mathias Kranz, Winnie Deuther-Conrad, Peter Brust, Martin E. Lidell, Matthias J. Betz, Sven Enerbäck, Jürgen Schrader, Gennady G. Yegutkin, Christa E. Müller, Alexander Pfeifer;
    Adenosine activates brown adipose tissue and recruits beige adipocytes via A2A receptors.
    Nature 2014, 516, 395-399.
  • Z. Gordon Jiang, Yan Wu, Eva Csizmadia, Linda Feldbrügge, Keiichi Enjyoji, John Tigges, Vasilis Toxavidis, Holger Stephan, Christa E. Müller, C. James McKnight, Alan Moss, Simon C. Robson;
    Characterization of circulating microparticle-associated CD39 family ecto-nucleotidases in human plasma.
    Purinergic Signal. 2014, 10, 611-618.
  • Marianne Freundlieb, Herbert Zimmermann, Christa E. Müller;
    A new sensitive ecto-5‘-nucleotidase assay for compound screening.
    Anal. Biochem. 2014, 446, 53-58.
  • Annalisa Pinna, Jordi Bonaventura, Daniel Farré, Marta Sánchesz, Nicola Simola, Josefa Mallol, Carme Lluís, Giulia Costa, Younis Baqi, Christa E. Müller, Antoni Cortés, Peter McCormick, Enric I. Canela, Eva Martínez-Pinilla, José L. Lanciego, Vicent Casadó, Marie-Therese Armentero, Rafael Franco;
    L-DOPA disrupts adenosine A2A-cannabinoid CB1-dopamine D2 receptor heteromer cross-talk in the striatum of hemiparkinsonian rats: Biochemical and behavioral studies.
    Exp. Neurol. 2014, 253, 180-191.
  • Cyril Laurent, Sylvie Burnouf, B. Ferry, Vânia L. Batalha, Joana E. Coelho, Younis Baqi, Enas Malik, Elodie Marciniak, S. Parrot, Ann Van der Jeugd, E. Faivre, V. Flaten, Catherine Ledent, Rudi D’Hooge, Nicolas Sergeant, Malika Hamdane, Sandrine Humez, Christa E. Müller, Luisa V. Lopes, Luc Buée, David Blum;
    A2A adenosine receptor deletion is protective in a mouse model of tauopathy.
    Mol. Psychiatry 2014, 1-11.

     

    2013

    • Vânia L. Batalha, José M. Pego, Bruno M. Fontinha, Ana R. Costenla, Jorge S. Valadas, Younis Baqi, Hamid Radjainia, Christa E. Müller, Ana M. Sebastião, Luisa V. Lopes;
      Adenosine A2A receptor blockade reverts hippocampal stress-induced deficits and restores corticosterone circadian oscillation.
      Mol. Psych. 2013, 18, 320-331.
    • Philippe Ohlmann, Anna Lecchi, Ali El-Tayeb, Christa E. Müller, Marco Cattaneo, Christian Gachet;
      The platelet P2Y12 receptor under normal and pathological conditions. Assessment with the radiolabeled selective antagonist [3H]PSB-0413.
      Purinergic Signal. 2013, 9, 59-66.
    • Benjamin F. Seibt, Anke C. Schiedel, Dominik Thimm, Sonja Hinz, Farag F. Sherbiny, Christa E. Müller;
      The second extracellular loop of GPCRs determines subtype-selectivity and controls efficacy as evidenced by loop exchange study at A2 adenosine receptors.
      Biochem. Pharmacol. 2013, 85, 1317-1329.
    • Jamshed Iqbal, Shoaib Iqbal, Christa E. Müller;
      Advances in immobilized Enzyme microbioreactors in capillary electrophoresis.
      Analyst 2013, 138, 3104-3116.
    • Anne Stößel, Miriam Schlenk, Sonja Hinz, Petra Küppers, Jag Heer, Michael Gütschow, Christa E. Müller;
      Dual targeting of adenosine A2A receptors and monoamine oxidase B by 4H-3,1-benzothiazin-4-ones.
      J. Med. Chem. 2013, 56, 4580-4596. 
    • Viktor Rempel, Nicole Volz, Franziska Gläser, Martin Nieger, Stefan Bräse, Christa E. Müller;
      Antagonists for the orphan G-protein-coupled receptor GPR55 based on a coumarin scaffold.
      J. Med. Chem. 2013, 56, 4798-4810.
    • Mario Funke, Dominik Thimm, Anke C. Schiedel, Christa E. Müller;
      8-Benzamidchormen-4-one-2-carboxylic acids - potent and selective agonists for the orphan G protein-coupled receptor GPR35.
      J. Med. Chem. 2013, 56, 5182-5197.
    • Dominik Thimm, Anke C. Schiedel, Farag F. Sherbiny, Sonja Hinz, Katharina Hochheiser, Daniela C.G. Bertarelli, Astrid Maaß, Christa E. Müller;
      Ligand-specific binding and activation of the human adenosine A2B receptor.
      Biochemistry 2013, 52, 726-740.
    • Samantha J. Podurgiel, Eric J. Nunes, Samantha E. Yohn, James Barber, Alexis Thompson, Meredith Milligan, Christie A. Lee, Laura López-Cruz, Marta Pardo, Olga Valverde, Catherine Ledent, Younis Baqi, Christa E. Müller, Mercé Correa. John D. Salamone;
      The vesicular monoamine transporter (vmat-2) inhibitor tetrabenazine induces tremulous jaw movements in rodents: implications for pharmacological models of parkinsonian tremor.
      Neuroscience 2013, 250C, 507-519.
    • Elisabete Augusto, Marco Matos, Jean Sévigny, Ali El-Tayeb, Margaret S. Bynoe, Christa E. Müller, Rodrigo A. Cunha, and Jiang-Fan Chen;
      Ecto-5′-nucleotidase (CD73)-mediated formation of adenosine is critical for the striatal adenosine A2A receptor functions.
      J. Neurosci. 2013, 33, 11390-11399.
    • Mario Funke, Dominik Thimm, Anke C. Schiedel, Christa E. Müller;
      8-Benzamidochromen-4-one-2-carboxylic acids: potent and selective agonists for the orphan G protein-coupled receptor GPR35.
      J. Med. Chem. 2013, 56, 5182-5197.
    • Viktor Rempel, Nicole Volz, Franziska Gläser, Martin Nieger, Stefan Bräse, Christa E. Müller;
      Antagonists for the orphan G protein-coupled receptor GPR55 based on a coumarin scaffold.
      J. Med. Chem. 2013, 56, 4798-4810.
    • Bellamkonda K. Kishore, Yue Zhang, Haykanush Gevorgyan, Donald E. Kohan, Anke C. Schiedel, Christa E. Müller, János Peti-Peterdi;
      Cellular localization of adenine receptors in the rat kidney and their functional significance in the inner medullary collecting duct.
      Am. J. Physiol. Renal. Physiol. 2013, 305, F1298–F1305.
    • Lyndsey E. Collins-Praino, Nicholas E. Paul, Felicia Ledgard, Samantha J. Podurgiel, Rotem Kovner, Younis Baqi, Christa E. Müller, Patrick B. Senatus, John D. Salamone;
      Deep brain stimulation of the subthalamic nucleus reverses oral tremor in pharmacological models of parkinsonism: interaction with the effects of adenosine A2A antagonism.
      Eur. J. Neurosci. 2013, 38, 2183-2191.
    • Anna Drabczyńska, Tadeusz Karcz, Ewa Szymańska, Meryem Köse, Christa E. Müller, Minka Paskaleva, Janina Karola-Wojciechowsa, Jadwiga Handzlik, Olga Yuzlenko, Katarzyna Kieć-Kononowicz;
      Synthesis, biological activity and molecular modelling studies of tricyclic alkylimidazo-, pyrimido- and diazepinopurinediones.
      Purinergic Signal. 2013, 9, 395-414. 
    • Carla G. Silva, Christine Métin, Walid Fazeli, Nuno J. Machado, Sanja Darmopil, Pierre-Serge Launay, Antoine Ghestem, Marie-Pascale Nesa, Emilie Bassot, Eszter Szabó, Younis Baqi, Christa E. Müller, Angelo R. Tomé, Anton Ivanov, Dirk Isbrandt, Yuri Zilberter, Rodrigo A. Cunha, Monique Esclapez, Christophe Bernard;
      Adenosine receptor antagonists including caffeine alter fetal brain development in mice.
      Sci. Transl. Med. 2013, 5, 197ra104. 
    • Marta Pardo, Laura López-Cruz, Olga Valverde, Catherine Ledent, Younis Baqi, Christa E. Müller, John D. Salamone, Mercé Correa;
      Effect of subtype-selective adenosine receptor antagonists on basal or haloperidol-regulated striatal function: studies of exploratory locomotion and c-Fos immunoreactivity in outbred and A2A R KO mice.
      Behav. Brain Res. 2013, 247, 217-226.
    •  John D. Salamone, Lyndsey E. Collins-Praino, Marta Pardo, Samantha J. Podurgiel, Younis Baqi, Christa E. Müller, Michael A. Schwarzschild, Mercé Correa;
      Conditional neural knockout of the adenosine A2A receptor and pharmacological A2A antagonism reduce pilocarpine-induced tremulous jaw movements: Studies with a mouse model of parkinsonian tremor.
      Eur. Neuropsychopharmacol. 2013, 23, 972-977.
    • Holger Stephan, Manja Kubeil, Franziska Emmerling, Christa E. Müller;
      Polyoxometalates as versatile enzyme inhibitors.
      Eur. J. Inorg. Chem. 2013, 1585-1594.

     

    • Pierre Koch, Rhalid Akkari, Andreas Brunschweiger, Thomas Borrmann, Miriam Schlenk, Petra Küppers, Meryem Köse, Hamid Radjainia, Jörg Hockemeyer, Anna Drabczyńska, Katarzyna Kieć-Kononowicz, Christa E. Müller;
      1,3-Dialkyl-substituted tetrahydropyrimido[1,2-f]purine-2,4-diones as multiple target drugs for the potential treatment of neurodegenerative diseases.
      Bioorg. Med. Chem. 2013, 21, 7435–7452.
    • Stephanie Hennen, Haibo Wang, Lucas Peters, Nicole Merten, Katharina Simon, Andreas Spinrath, Stefanie Blättermann, Rhalid Akkari, Ramona Schrage, Ralf Schröder, Daniel Schulz, Celine Vermeiren, Katrin Zimmermann, Stefan Kehraus, Christel Drewke, Alexander Pfeifer, Gabriele M. König, Klaus Mohr, Michel Gillard, Christa E. Müller, Q. Richard Lu, Jesús Gomeza, Evi Kostenis;
      Decoding signaling and function of the orphan G protein-coupled receptor GPR17 with a small-molecule agonist.
      Sci. Signal. 2013, 6, 1-16.
    • Melanie Knospe, Christa E. Müller, Patrizia Rosa, Aliaa Abdelrahman, Ivar von Kügelgen, Dominik Thimm, Anke C. Schiedel;
      The rat adenine receptor: pharmacological characterization and mutagenesis studies to investigate its putative ligand binding site.
      Purinergic Signal. 2013, 9, 367-381.
    • Dominik Thimm, Melanie Knospe, Aliaa Abdelrahman, Miguel Moutinho, Bernt B. A. Alsdorf, Ivar von Kügelgen, Anke C. Schiedel, Christa E. Müller;
      Characterization of new G protein-coupled adenine receptors in mouse and hamster.
      Purinergic Signal. 2013, 9, 415-426.
    • Edith Hochhauser, Ronit Cohen, Maayan Waldman, Anna Maksin, Ahuva Isak, Dan Aravot, P. Suresh Jayasekara, Christa E. Müller, Kenneth A. Jacobson, Asher Shainberg;
      P2Y2 receptor agonist with enhanced stability protects the heart from ischemic damage in vitro and in vivo.
      Purinergic Signal. 2013, 9, 633-642.
    • Alexander Fuchs, Victor Rempel, Christa E. Müller;
      The natural structure magnolol as a lead structure for the development of potent cannabinoid receptor agonists.
      PLOS one 2013, 8, e77739.
    • Eric J. Nunes, Patrick A. Randall, Evan E. Hart, Charlotte Freeland, Samantha E. Yohn, Younis Baqi, Christa E. Müller, Laura López-Cruz, Mercé Correa, John D. Salamone;
      Effort-related motivational effects of the VMAT-2 inhibitor tetrabenazine: implications for animal models of the motivational symptoms of depression.
      J. Neurosci. 2013, 33, 19120-19130.
    • Anke C. Schiedel, Svenja Lacher, Carsten Linnemann, Percy A. Knolle, Christa E. Müller;
      Antiproliferative effects of selective adenosine receptor agonists and antagonists on human lymphocytes: evidence for receptor-independent mechanisms.
      Purinergic Signal. 2013, 9, 351-365.
    • Dominik Thimm, Mario Funke, Anne Meyer, Christa E. Müller;
      6-Bromo-8-(4-[3H]methoxybenzamido)-4-oxo-4H-chromene-2-carboxylic acid: a powerful tool for studying orphan G protein-coupled receptor GPR35.
      J. Med. Chem. 2013, DOI 10.1021/jm4009373.
    • Fabian Heisig, Sabrina Gollos, Sven J. Freudenthal, Ali El-Tayeb, Jamshed Iqbal, Christa E. Müller;
      Synthesis of BODIPY derivatives substituted with various bioconjugatable linker groups: A construction kit for fluorescent labeling of receptor ligands.
      J. Fluoresc. 2013, 23, DOI 10.1007/s10895-013-1289-4.
    • Eric E. Nunes, Patrick A. Randall, Alexavier Estrada, Brian Epling, Evan H. Hart, Christie A. Lee, Younis Baqi, Christa E. Müller, Mercé Correa, John D. Salamone;
      Effort-related motivational effects of the pro-inflammatory cytokine interleukin 1-beta: studiese with the concurrent fixed ratio 5/ chow feeding choice task.
      Psychopharmacol.
      2013, DOI 10.1007/s00213-013-3285-4 

    2012 

    • Patrick A. Randall, Marta Pardo, Eric J. Nunes, Laura López Cruz, V. Kiran Vermurei, Alex Makriyannis, Younis Baqi, Christa E. Müller, Mercè Correa, John D. Salamone;
      Dopaminergic modulation of effort-related choice behavior as assessed by a progressive ratio chow feeding choice task: pharmacological studies and the role of individual differences.
      PLOS ONE 2012, 53, 1-10.
    • Younis Baqi, Christa E. Müller;
      Efficient and mild deamination procedure for 1-aminoanthraquinones yielding  a diverse library of novel derivatives with potential biological activity.
      Tetrahedron letters 2012, 53, 6739-6742.
    • Viktor Rempel, Nicole Volz, Sonja Hinz, Tadeusz Karcz, Irene Meliciani, Martin Nieger, Wolfgang Wenzel, Stefan Bräse, Christa E. Müller;
      7-Alkyl-3-benzylcoumarins: a versatile scaffold for the development of potent and selective cannabinoid receptor agonists and antagonists.
      J. Med. Chem. 2012, 55, 7967-7977.
    • Sang-Yong Lee, Sébastien A. Lévesque, Jean Sévigny, Christa E. Müller;
      A highly sensitive capillary electrophoresis method using p-nitrophenyl 5'-thymidine monophosphate as a substrate for the monitoring of nucleotide pyrophosphatase/phosphodiesterase activities.
      J. Chromatogr. B 2012, 55, 162-169.
    • Victor Hernández-Olmos, Aliaa Abdelrahman, Ali El-Tayeb, Diana Freudendahl, Stephanie Weinhausen, Christa E. Müller;
      N-Substituted phenoxazine and acridone derivatives: structure-activity relationships of potent P2X4 receptor antagonists.
      J. Med. Chem. 2012, 55, 9576-9588.
    • Karen Knapp, Matthias Zebisch, Jan Pippel, Ali El-Tayeb, Christa E. Müller, Norbert Sträter;
      Crystal structure of the human ecto-5'-nucleotidase (CD73): insights into the regulation of puringic signalling.
      Stucture 2012, 20, 2161-2173.
    • Nikolay T. Tzvetkov, Harald Euler, Christa E. Müller;
      Regioselective synthesis of 7,8-dihydroimidazo[5,1-c][1,2,4]triazine-3,6(2H,4H)-dione derivatives: A new drug-like heterocyclic scaffold.
      Beilstein J. Org. Chem. 2012, 8, 1584-1593.
    • Ulrich Flögel, Sandra Burghoff, Peter L.E.M. van Lent, Sebastian Temme, Lisa Galbarz, Zhaoping Ding, Ali El-Tayeb, Sandra Huels, Florian Bönner, Nadine Borg, Christoph Jacoby, Christa E. Müller, Wim B. van den Berg, Jürgen Schrader; Selective activation of adenosine A2A receptors on immune cells by a CD73 dependent prodrug suppresses joint inflammation in experimental rheumatoid arthritis.
      Science Transl. Med. 20124, 1-8.  
    • Nikolay Tzvetkov, Christa E. Müller;
      Facile synthesis of 5-amino and 7-amino-6-azaoxindole derivatives.
      Tetrahedron Lett. 2012, 53, 5597-5601.
    • Simone Hildenbrand, Susanne Schoch, Marec von Lehe, Rainer Surges, Christa E. Müller;
      Tritium-Labeled Brivaracetam with High Specific Activity: Preparation, Characterization and Application in Human Brain Samples.
      ChemMedChem 2012, 7, 1369-1374.
    • Carl Högberg, Olof Gidlöf, Francesca Deflorian, Kenneth A. Jacobson, Aliaa Abdelrahman, Christa E. Müller, Björn Olde, David Erlinge;
      Farnesyl pyrophosphate is an endogenous antagonist to ADP-stimulated P2Y12 receptor-mediated platelet aggregation.
      Thromb. Haemost. 2012, 108, 119-132.
    • Peter Ripphausen, Marianne Freundlieb, Andreas Brunschweiger, Herbert Zimmermann, Christa E. Müller, Jürgen Bajorath;
      Virtual screening identifies novel sulfonamide inhibitors of ecto-5‘-nucleotidase.
      J. Med. Chem. 2012, 55, 6576-6581.
    • Jessica S. Santerre, Eric J. Nunes, Rotem Kovner, Chelsea E .Leser, Patrick A. Randall, Lyndsey E. Collins-Praino, Laura Lopez Cruz, Merce Correa, Younis Baqi, Christa E. Müller, John D. Salamone.
      The novel adenosine A2A antagonist prodrug MSX-4 is effective in animal models related to motivational and motor functions.
      Pharmacology, Biochemistry and Behavior 2012, 102, 477-487.
    • Christa E. Müller, Anke C. Schiedel, Younis Baqi;
      Allosteric modulators of rhodopsin-like G protein-coupled receptors: opportunities in drug development.
      Pharmacol. Ther. 2012, 135, 292-315.
    • Marta Pardo, Laura Lopez-Cruz, Olga Valverde, Catherine Ledent, Younis Baqi, Christa E. Müller, John D. Salamone, Merce Correa;
      Adenosine A2A receptor antagonism and genetic deletion attenuate the effects of dopamine D2 antagonism on effort-based decision making in mice.
      Neuropharmacology 2012, 62, 2068-2077. 
    • Renata Ciccarelli, Christa E. Müller, Herbert Zimmermann;
      International conference on purinergic drugs and targets – 4th joint German-Italian purine club meeting, Bonn, Germany, July 22-25, 2011.
      Purinergic Signal. 2012, 8, 105-106.
    • Sebastian Michael, Haba Abdel-Aziz, Dieter Weiser, Christa E. Müller, Olaf Kelber, Karen Nieber;
      Adenosine A2A receptor contributes to the anti-inflammatory effect of the fixed herbal combination STW5 (Iberogast®) in rat small intestinal preparations.
      Naunyn-Schmiedeberg’s Arch. Pharmacol. 2012, 385, 411-421.
    • Sebastian Michael, H.-W. Rauwald, Haba Abdel-Aziz, Dieter Weiser, Christa E. Müller, Olaf Kelber, Karen Nieber;
      Adenosine receptors: new targets to protect against tissue damage in inflammatory bowel symptoms. Sami Karoui (ed.) Inflammatory Bowel Disease – Advances in Pathogenesis and Management, 42-58, 2012
    • Alessia Melani, Francesca Corti, Holger Stephan, Christa E. Müller, Paola Bruni, Maria G. Vannucchi, Felicita Pedata;
      Ecto-ATPase inhibition: ATP and adenosine release under physiological and ischemic in vivo conditions in the rat striatum.
      Exp. Neurol. 2012, 233, 193-204. 
    • Younis Baqi, Christa E. Müller;
      Convergent synthesis of the potent P2Y receptor antagonist MG 50-3-1 based on a regioselective Ullmann coupling reaction.
      Molecules 2012, 17, 2599-2615. 
    • Michael Gütschow, Miriam Schlenk, Jürgen Gäb, Minka Paskaleva, Muhamad Wessam Alnouri, Silvia Scolari, Jamshed Iqbal, Christa E. Müller;
      Benzothiazinones: A novel class of adenosine receptor antagonists structurally unrelated to xanthine and adenine derivatives.
      J. Med. Chem. 2012, 55, 3331-3341.

    2011 

    • Younis Baqi, Ralf Hausmann, Christiane Rosefort, Jürgen Retting, Günther Schmalzing, Christa E. Müller;

      Discovery of potent competitive antagonists and positive modulators of the P2X2 receptor.

      J. Med. Chem. 2011, 54, 817-830.

    • Christa E. Müller, Kenneth A. Jacobson;
      Xanthines as Adenosine Receptor antagonists. B.B. Fredholm (ed.) Handbook of Experimental Pharmacology, Vol. 200, Methylxanthines, 151-199, 2011.
    • Christa E. Müller;
      Purinrezeptoren als Zielstrukturen in der Arzneimittelforschung.
      Biospektrum 2011, 17, 645-648.
    • Mahmoud Fahmi Elsebai, Viktor Rempel, Gregor Schnakenburg, Stefan Kehraus, Christa E. Müller, Gabriele M. König;
      Identification of a potent and selective cannabinoid CB1 receptor antagonist from Auxarthron reticulatum.
      Med. Chem. Lett. 2011, 2, 866-869.
    • Ali El-Tayeb, Sebastian Michael, Aliaa Abdelrahmen, Andrea Behrenswerth, Sabrina Gollos, Karen Nieber, Christa E. Müller;
      Development of polar adenosine A2A receptor agonists for inflammatory bowel disease: synergism with A2B antagonists.
      ACS Med. Chem. Lett. 2011, 2, 890-895.
    • Marie Therese Armentero, Annalisa Pinna, Sergi Ferré, José Luis Lanciego, Christa E. Müller, Rafael Franco;
      Past, present and future of A2A adenosine receptor antagonists in the therapy of Parkinson’s disease;
      Pharmacology & Therapeutics 2011, 132, 280-299.
    • Anna Drabczyńska, Olga Yuzlenko, Meryem Köse, Minka Paskaleva, Anke C. Schiedel, Janina Karolak-Wojciechowska, Jadwiga Handzlik, Tadeusz Karcz, Kamil Kuder, Christa E. Müller, Katarzyna Kieć-Kononowicz;
      Synthesis and biological activity of tricyclic cycloalkylimidazo-, pyrimido- and diazepinopurinediones.
      Eur. J. Med. Chem. 2011, 46, 3590-3607. 
    • Zuzana Justinová, Sergi Ferré, Godfrey H. Redhi, Paola Mascia, Jessica Stroik, Davide Quarta, Sevil Yasar, Christa E. Müller, Rafael Franco, Steven R. Goldberg;
      Reinforcing and neurochemical effects of cannabionid CB1 receptor agonists, but not cocaine, are altered by an adenosine A2A receptor antagonist.
      Addict. Biol. 2011, 16, 405-415. 
    • Patrick A. Randall, Eric J. Nunes, Simone L. Janniere, Colin M. Stopper, Andrew M. Farrar, Thomas N. Sager, Younis Baqi, Jörg Hockemeyer, Christa E. Müller, John D. Salamone;
      Stimulant effects of adenosine antagonists on operant behaviour: differential actions of selective A2A and A1 antagonists.
      Psychopharmacology 2011, 216, 173-186.
    • Anke C. Schiedel, Sonja Hinz, Dominik Thimm, Faraq Sherbiny, Thomas Borrmann, Astrid Maaß, Christa E. Müller;
      The four cysteine residues in the second extracellular loop of the human adenosine A2B receptor: Role in ligand binding and receptor function.
      Biochem. Pharmacol. 2011, 82, 389-399.
    • Ali El-Tayeb, Aidong Qi, Robert A. Nicholas, Christa E. Müller;
      Structural modifications of UMP, UDP and UTP leading to subtype-selective agonists for P2Y2, P2Y4, and P2Y6 receptors.
      J. Med. Chem. 2011, 54, 2878-2890.
    • Mariana Pereira, Andrew M. Ferrar, Jörg Hockemeyer, Christa E. Müller, John D. Salamone, Joan I. Morrell;
      Effect of the adenosine A2A receptor antagonist MSX-3 on motivational disruptions of maternal behavior induced by dopamine antagonism in the early postpartum rat.
      Psychopharmacology 2011, 213, 69-79.
    • Jamshed Iqbal, Christa E. Müller;
      High-sensitivity capillary electrophoresis method for monitoring purine nucleoside phosphorylase and adenosine deaminase reactions by a reversed electrode polarity switching mode.
      J. Chromatogr. A 2011, 1218, 4764-4771.
    • Lyndsey E. Collins, Nicholas E. Paul, Shams F. Abbas, Chelsea E. Leser, Samantha J. Podurgiel, Daniel J. Galtieri, James J. Chrobak, Younis Baqi, Christa E. Müller, John D. Salamone;
      Oral tremor induced by galantamine in rats: A model of the parkinsonian side effects of cholinomimentics used to treat Alzheimer’s.
      Pharmacol. Biochem. Behav. 2011, 99, 414-422.
    • Anne Pick, Henrik Müller, Ralf Mayer, Britta Haenisch, Ilza K. Pajeva, Mathias Weigt, Heinz Bönisch, Christa. E. Müller, Michael Wiese;
      Structure-activity relationships of flavonoids as inhibitors of breast cancer resistance protein (BCRP).
      Bioorg. Med. Chem. 2011, 19, 2090-2102.
    • Bertil B. Fredholm, Adriaan P. IJzerman, Kenneth A. Jacobson, Joel Linden, Christa E. Müller;
      Nomenclature and classification of adenosine receptors – An update.
      Pharmacol. Rev. 2011, 63, 1-34.
    • Miriam C. Peeters, Gerard J. P. van Westen, Dong Guo, Lisanne E. Wisse, Christa E. Müller, Margot W. Beukers, Adriaan P. IJzerman;
      GPCR structure and activation: an essential role for the first extracellular loop in activating the adenosine A2B receptor.
      FASEB J. 2011, 25,632-643.
    • Christa E. Müller, Kenneth A. Jacobson;
      Recent developments in adenosine receptor ligands and their potential as novel drugs.
      Biochim. Biophys. Acta – Biomembranes 2011, 1290-1308.
    • Anna Drabczyńska, Małgorzata Zygmunt, Jacek Sapa, Barbara Filipek, Christa E. Müller, Katarzyna Kieć-Kononowicz;
      Antiparkinsonian effects of novel adenosine A2A receptor antagonists.
      Arch. Pharm. Chem. Life Sci. 2011, 344,20-27.  

    2010 

    • Sandra Dettmann, Katrin Szymanowitz, Anja Wellner, Anke Schiedel, Christa E. Müller;
      2-Phenyl-1-[4-(2-piperidine-1-yl-ethoxy)benzyl]-1H-benzimidazoles as ligands for the estrogen receptor: Synthesis and pharmacological evaluation.
      Bioorg. Med. Chem. 2010, 18, 4905-4916.
    • Harald Euler, Armin Kirfel, Amelie Zech, Jörg Hockemeyer, Christa E. Müller;
      Crystal structure of 6-amino-3-cyclopropyl-1-ethyl-1H-pyrimidine-2,4-dione hydrate, C9H13N3O2H2O.
      Z. Kristallogr. NCS 2010, 225, 595-596.
    • Lyndsey E. Collins, Daniel J. Galtieri, Patricia Collins, Shawnet K. Jones, Russel G. Port, Nicholas E. Paul, Jörg Hockemeyer, Christa E. Müller, John D. Salamone;
      Interactions between adenosine and dopamine receptor antagonists with different selectivity profiles: Effects on locomotor activity.
      Behav. Brain Res. 2010, 211, 148-155.
    • Younis Baqi, Christa E. Müller;
      Synthesis of alkyl- and aryl-amino-substituted anthraquinone derivatives by microwave-assisted copper(0)-catalyzed Ullmann coupling reactions.
      Nat. Protocols 2010, 5, 945-953.
    • Lyndsey E. Collins, Daniel J. Galtieri, Lise T. Brennum, Thomas N. Sager, Jörg Hockemeyer, Christa E. Müller, James R. Hinman, James J. Chrobak, John D. Salamone;
      Oral tremor induced by the muscarinic agonist pilocarpine is suppressed by the adenosine A2A antagonists MSX-3 and SCH58261, but not the adenosine A1 antagonist DPCPX.
      Pharmacology, Biochemistry and Behavior 2010, 94, 561-569.
    • Sebastian Michael, Claudia Warstat, Fabien Michel, Luo Yan, Christa E. Müller, Karen Nieber;
      Adenosine A2A agonist and A2B antagonist mediate an inhibition of inflammation-induced contractile disturbance of a rat gastrointestinal preparation.
      Purinergic Signal. 2010, 6, 117-124.
    • Anja B. Scheiff, Swapnil G. Yerande, Ali El-Tayeb, Wenjin Li, Gajanan S. Inamdar, Kamala K. Vasu, Vasudevan Sudarsanam, Christa E. Müller;
      2-Amino-5-benzoyl-4-phenylthiazoles: development of potent and selective adenosine A1 receptor antagonists.
      Bioorg. Med. Chem. 2010, 18, 2195-2203.
    • Andrew M. Farrar, Kristen N. Segovia, Patrick A. Randall, Lyndsey E. Collins, Eric J. Nunes, Colin Stopper, Jörg Hockemeyer, Christa E. Müller, Merce Correa, John D. Salamone;
      Nucleus accumbens and effort-related functions: behavioural and neural markers of the interactions between adenosine A2A and dopamine D2 receptors.
      Neuroscience 2010166, 1056-1067.
    • Thomas Emmrich, Ali El-Tayeb, Hesham Taha, Roland Seifert, Christa E.Müller, Andreas Link;
      Synthesis of a hydrolytically stable, fluorescent-labeled ATP analog as a tool for probing adenylyl cyclases.
      Bioorg. Med. Chem. Lett. 2010, 20, 232-235.
    • Giana P. Cognato, Paula M. Agostinho, Jörg Hockemeyer, Christa E. Müller, Diogo O. Souza, Rodrigo A. Cunha;
      Caffeine and an adenosine A2A receptor antagonist prevent memory impairment and synaptotoxicity in adult rats triggered by a convulsive episode in early life.
      J. Neurochem. 2010, 112, 453-462.
    • Jamshed Iqbal, Aileen Knowles, Christa E. Müller;
      Development of a microbioreactor with ecto-nucleoside triphosphate diphosphohydrolase 2 (NTPDase2) immobilized on a polyacrylamide-coated capillary at the outlet.
      J. Chromatogr. A, 2010, 1217, 600-604. 
    • Younis Baqi, Sang-Yong Lee, Jamshed Iqbal, Peter Ripphausen, Anne Lehr, Anja B. Scheiff, Herbert Zimmermann, Jürgen Bajorath, Christa E. Müller;
      Development of potent and selective inhibitors of ecto-5’-nucleotidase based on an anthraquinone scaffold.
      J. Med. Chem. 2010, 53, 2076-2086. 
    • Xiaofeng Sun, Yan Wu, Wenda Gao, Keiichi Enjyoji, Eva Csizmadia, Christa E. Müller, Takashi Murakami, Simon C. Robson;
      CD39/ENTPD1 expression by CD4+Foxp3+ regulatory T cells promotes hepatic metastatic tumor growth in mice.
      Gastroenterology 2010139, 1030-1040.
    • Christa E. Müller, Sergi Ferré;
      Blocking striatal adenosine A2A receptors: a new strategy for basal ganglia disorders;
      Frontiers in CNS Drug Discovery 2010, 1, 304-341.
    • Christa E. Müller;
      Emerging structures and ligands for P2X3 and P2X4 receptors - towards novel treatments of neuropathic pain.
      Purinergic Signal. 2010, 6, 145-148.

    2009

    • Harald Euler, Bruno Barbier, Nikolay T. Tzvetkov, Christa E. Müller;
      Crystal structure of 3-benzyl-5,5-dimethylimidazolidine-2,4-dione, C12H14N2O2.
      Z. Kristallogr. NCS 2009, 224, 601-602 .
    • Ali El-Tayeb, Jamshed Iqbal, Andrea Behrenswerth, Michael Romio, Marion Schneider, Herbert Zimmermann, Jürgen Schrader, Christa E. Müller;
      Nucleoside-5’monophosphates as prodrugs of adenosine A2A receptor agonists activated by ecto-5’-nucleotidase.
      J. Med. Chem. 2009, 52, 7669-7677.
    • Christa E. Müller;
      Prodrug approaches for enhancing the bioavailability of drugs with low solubility.
      Chemistry & Biodiversity 2009, 6, 2071-2083.
    • Faraq F. Sherbiny, Anke C. Schiedel, Astrid Maaß, Christa. E. Müller;
      Homology modelling of the human adenosine A2B receptor based on X-ray structures of bovine rhodopsin, the β2-adrenergic receptor and the human adenosine A2A receptor.
      J. Comput. Aided Mol. Des. 2009, 23, 807-828.
    • Thomas Borrmann, Aliaa Abdelrahman, Rosaria Volpini, Catia Lambertucci, Edgars Alksnis, Simone Gorzalka, Melanie Knospe, Anke C. Schiedel, Gloria Cristalli, Christa E. Müller;
      Structure-activity relationships of adenine and deazaadenine derivatives as ligands for adenine receptors, a new purinergic receptor family.
      J. Med. Chem. 200952, 5974-5989.
    • Carina Klein, Anja Grahnert, Aliaa Abdelrahman, Christa E. Müller, Sunna Hauschildt;
      Extracellular NAD+ induces a reise in [Ca2+] in activated human monocytes via engagement of P2Y1 and P2Y11 receptors.
      Cell Calcium 2009, 46, 263-272.
    • Kristina Hoffmann, Younis Baqi, María S. Morena, Markus Glänzel, Christa E. Müller, Ivar von Kügelgen;
      Interaction of new, very potent non-nucleotide antagonists with Arg256 of the human platelet P2Y12 receptor.
      J. Pharmacol. Exp. Ther. 2009, 331, 648-655.
    • Carsten Linnemann, Frank A. Schildberg, Anna Schurich, Linda Diehl, Silke I. Hegenbarth, Elmar Endl, Svenja Lacher, Christa E. Müller, Jürgen Frey, Luca Simeoni, Burkhart Schraven, Dirk Stabenow, Percy A. Knolle;
      Adenosine regulates CD8 T-cell priming by inhibition of membrane-proximal T-cell receptor signalling.
      Immunology 2009, 128, 728-737.
    • Roland Sauer, Ali El-Tayeb, Marko Kaulich, Christa E. Müller;
      Synthesis of uracil nucleotide analogs with a modified, acyclic ribose moiety as P2Y2 receptor antagonists.
      Bioorg. Med. Chem. 2009, 17, 5071-5079.
    • Thomas Borrmann, Sonja Hinz, Daniela C. G. Bertarelli, Wenjin Li, Nicole C. Florin, Anja B. Scheiff, Christa E. Müller;
      1-Alkyl-8-(piperazine-1-sulfonyl)phenylxanthines: development and characterization of adenosine A2B receptor antagonists and a new radioligand with subnanomolar affinity and subtype specifity.
      J. Med. Chem. 2009, 52, 3994-4006
    • Younis Baqi, Kerstin Atzler, Meryem Köse, Markus Glänzel, Christa E. Müller;
      High-affinity, non-nucleotide-derived competitive antagonists of platelet P2Y12 receptors.
      J. Med. Chem. 2009, 52, 3784-3793.
    • Petra Hillmann, Geun-Yung Ko, Andreas Spinrath, Alexandra Raulf, Ivar von Kügelgen, Samuel C. Wolff, Robert A. Nicholas, Evi Kostenis, Hans-Dieter Höltje and Christa E. Müller
      Key determinants of nucleotide-activated G protein-coupled P2Y2 receptor function revealed by chemical and pharmacological experiments, mutagenesis and homology modeling.
      J. Med. Chem., 2009, 52, pp 2762–2775.
    • Harald Euler, Armin Kirfel, Ali El-Tayeb, Christa E. Müller;
      Crystal structure of 1-(2R, 3R, 4S, 5R)-3,4-dihydroxy-5-hydroxymethyl-tetrahydrofuran-2-yl-2-propylsulfanyl-1H-pyrimidin-4-one, C12H18N2O5S.
      Z. Kristallogr. NCS 2009, 224, 107-108.
    • Younis Baqi, Stefanie Weyler, Jamshed Iqbal, Herbert Zimmermann, Christa E. Müller;
      Structure-activity relationships of anthraquinone derivatives derived from bromaminic acid as inhibitors of ecto-nucleoside triphosphate diphosphohydrolases (E-NTPDases).
      Purinergic Signal. 2009, 5, 91-106.
    • Andrea Behrenswerth, Nicole Volz, Jakob Toräng, Sonja Hinz, Stefan Bräse, Christa E. Müller;
      Synthesis and pharmacological evaluation of coumarin derivatives of cannabinoid receptor antagonists and inverse agonists.
      Bioorg. Med. Chem. 2009, 2842-2851.
    • Christa E. Müller, Carolin Roegler, Jörg Hockemeyer;
      5,5’-Bipyridyl-2,4,6,2’,4’,6’-hexaone derivatives (hydurilic acids): syntheses, mechanism of C-C-bond formation and properties of the dimeric barbituric acid derivatives.
      Heterocycles 2009, 79, 703-720.
    • Lila Worden, Mona Shahriari, Andrew Farrar, Kelly S. Sink, Jörg Hockemeyer, Christa. E. Müller, John D. Salamone;
      The adenosine A2A antagonist MSX-3 reverses the effort-related effects of dopamine blockade: differential interaction with D1 and D2 family antagonists.
      Psychopharmacology 2009, 203, 489-499.
    • Allison M. Mott, Eric J. Nunes, Lyndsey E. Collins, Russell G. Port, Kelly S. Sink, Jörg Hockemeyer, Christa E. Müller, John D. Salamone;
      The adenosine A2A antagonist MSX-3 reverses the effects of the dopamine antagonist haloperidol on effort-related decision making in a T-maze cost/benefit procedure.
      Psychopharmacology 2009, 204, 103-112.
    • Gloria Cristalli, Christa E. Müller, Rosaria Volpini;
      Recent developments in adenosine A2A receptor ligands in: Wilson, Constance N.; Mustafa, S. Jamal (Hrsg.)
      Handbook of Experimental Pharmacology, Vol. 193, Adenosine Receptors in Health and Disease, 2009.
    • Elsbieta Pękala, Joachim C. Burbiel, Christa E. Müller;
      Preparation of enantiopure (R)-hydroxy metabolite of denbufylline using immobilized Lactobacillus kefiri DSM 20587 as a catalyst.
      Chirality 2009, 21, 713-718.

    2008

    • Fiona M. Sansom, Patrice Riedmaier, Hayley J. Newton, Michelle A. Dunstone, Christa E. Müller, Holger Stephan, Emma Byres, Travis Beddoe, Jame Rossjohn, Peter J. Cowan, Anthony J. F. d’Apice, Simon C. Robson, Elizabeth L. Hartland;
      Enzymatic properties of an ecto-nucleotidase triphosphate diphosphohydrolase from Legionella pneumophila: substrate specificity and requirement for virulence.
      J. Biol. Chem. 2008, 283, 12909-12918.
    • John D. Salamone, Adrienne J. Betz, Keita Ishiwari, Jennifer Felsted, Lisa Madson, Brian Mirante, Karen Clark, Laura Font, Samantha Korbey, Thomas N. Sager, Jörg Hockemeyer, Christa E. Müller;
      Tremorolytic effects of adenosine A2A antagonists: implications for parkinsonism.
      Front. Biosci. 2008, 13, 3594-3605.
    • Jamshed Iqbal, David Jirovsky, Sang-Yang Lee, Herbert Zimmermann, Christa E. Müller;
      Capillary electrophoresis-based nanoscale assays for monitoring ecto-5’-nucleotidase activity and inhibition in preparations of recombinant enzyme and melanoma cell membranes.
      Anal. Biochem. 2008, 373, 129-140.
    • Stefanie Weyler, Younis Baqi, Petra Hillmann, Marko Kaulich, Andrea M. Hunder, Ingrid A. Müller, Christa E. Müller;
      Combinatorial synthesis of anilinoanthraquinone derivates and evaluation as non-nucleotide-derived P2Y2 receptor antagonists.
      Bioorg. Med. Chem. Lett. 2008, 18, 223-227.
    • Ivar von Kügelgen, Anke C. Schiedel, K. Hoffmann, Bernt B. Alsdorf, Aliaa Abdelrahman, Christa E. Müller;
      Cloning and functional expression of a novel Gi protein-coupled receptor for adenine from mouse brain.
      Mol. Pharmacol. 2008, 73, 469-477.
    • Petra Hillmann, Meryem Köse, Kristina Söhl, Christa E. Müller;
      Ammonium-induced calcium mobilization in 1321N1 astrocytoma cells.
      Toxicol. Appl. Pharmacol. 2008, 227, 36-47.
    • Karl Vollmann, Ramatullah Qurishi, Jörg Hockemeyer, Christa E. Müller;
      Synthesis and properties of a new water-soluble prodrug of the adenosine A2A receptor antagonist MSX-2.
      Molecules 2008, 13, 348-359.
    • Andras Bilkei-Gorzo, Osama M. Abo-Salem, Alaa M. Hayallah, Kerstin Michel, Christa E. Müller, Andreas Zimmer;
      Adenosine receptor subtype-selective antagonists in inflammation and hyperalgesia.
      Naunyn-Schmiedebergs Arch. Pharmacol. 2008, 377, 65-76.
    • Geanne M. Cunha, Paula M. Canas, Carolina S. Melo, Jörg Hockemeyer, Christa E._Müller, Catarina R. Oliveira, Rodrigo A. Cunha;
      Adenosine A2A receptor blockade prevents memory dysfunction caused by beta-amyloid peptides but not by scopolamine or MK-801.
      Exp. Neurol. 2008, 210, 776-781.
    • Liqun Yu, Hai-Ying Shen, Joana E. Coelho, Inês M. Araújo, Qing-Yuan Huang, Yuan-Ji Day, Nelson Rebola, Paula M. Canas, Erica Kirsten Rapp, Jarrod Ferrara, Darcie Taylor, Christa E. Müller, Joel Linden, Rodrigo A. Cunha, Jiang-Fan Chen;
      A2A Receptors modulate motor activity and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine neurotoxicity by distinct cellular mechanisms.
      Ann. Neurol. 2008, 63, 338-346.
    • Daniel Marcellino, Paulina Carriba, Małgorzata Filip, Anders Borgkvist, Małgorzata Frankowska, Immaculada Bellido, Sergio Tanganelli, Christa E. Müller, Gilberto Fisone, Carme Lluis, Luigi F. Agnati, Rafael Franco, Kjell Fuxe;
      Antagonistic cannabinoid CB1/dopamine D2 receptor interactions in striatal CB1/D2 heteromers. A combined neurochemical and behavioural analysis.
      Neuropharmacology 2008, 54, 815-823.
    • Marcel Töpfer, Joachim C. Burbiel, Christa E. Müller, J. Knittel, Eugen J. Verspohl;
      Modulation of insulin release by adenosine A1 receptor agonists and antagonists in INS-1 cells: the possible contribution of 86Rb+ efflux and 45Ca2+ uptake.
      Cell Biochem. Funct. 2008, 26, 833-843.
    • Andreas Brunschweiger, Jamshed Iqbal, Frank Umbach, Anja B. Scheiff, Mercedes N. Munkonda, Jean Sévigny, Aileen F. Knowles, Christa E. Müller;
      Selective nucleoside triphosphate diphosphohydrolase-2 (NTPDase 2) inhibitors: nucleotide mimetics derived from uridine-5’-carboxamide.
      J. Med. Chem. 2008, 51, 4518 - 4528.
    • Jamshed Iqbal, Sébastien A. Lévesque, Jean Sévigny, Christa E. Müller;
      A highly sensitive CE-UV method with dynamic coating of silica-fused capillaries for the monitoring of nucleotide pyrophosphatase/phosphodiesterase reactions.
      Electrophoresis 2008, 29, 3685-3693.
    • Christa E. Müller;
      Parkinson-Therapeutika: Was gibt es Neues?
      Apotheken-Magazin – Fachmagazin für Pharm. Fortbildung 2008, 25, 8-12.
    • John D. Salamone, Keita Ishiwari, Adrienne J. Betz, Andrew M. Farrar, Susanna M. Mingote, Laura Font, Jörg Hockemeyer, Christa. E. Müller, Merce Correa;
      Dopamine/adenosine interactions related to locomotion and tremor in animal models: possible relevance to parkinsonism.
      Parkinsonism Relat. Disord. 2008, 14 Suppl. 2, S130-134.

    2007

    • Svenja K. Lacher, Ralf Mayer, Kathrin Sichardt, Karen Nieber, Christa E. Müller;
      Interaction of valerian extracts of different polarity with adenosine receptors: Identification of isovaltrate as an inverse agonist at A1 receptors.
      Biochem. Pharmacol. 2007, 73, 248-258.
    • Jamshed Iqbal, Leonardo Scapozza, Gerd Folkers, Christa E. Müller;
      Development and validation of a capillary electrophoresis method for the characterization of herpes simplex virus type 1 (HSV-1) thymidine kinase substrates and inhibitors.
      J. Chromatogr. B 2007, 846, 281-290.
    • Tadeusz Librowski, Monika Kubacka, Manuela Meusel, Silvia Scolari, Christa E. Müller, Michael Gütschow;
      Evaluation of anticonvulsant and analgesic effects of benzyl- and benzhydryl ureides.
      Eur. J. Pharmacol. 2007, 559, 138-149.
    • Christa E Müller and Sergi Ferré;
      Blocking striatal adenosine A2A receptors : a new strategy for basal ganglia disorders
      Recent Patents on CNS Drug Discovery, 2007, 2, 1-21.
    • Younis Baqi, Christa E. Müller;
      Rapid and efficient microwave-assisted copper(0)-catalyzed Ullmann coupling reaction: general access to anilinoanthraquinone derivatives.
      Org. Lett. 2007, 9, 1271-1274.
    • Almut Grenz, Hua Zhang, Marina Hermes, Tobias Eckle, Karin Klingel, Dan Yang Huang, Christa. E. Müller, Simon C. Robson, Hartmut Osswald, Holger Eltzschig;
      Contribution of E-NTPDase1 (CD39) to renal protection from ischemia-reperfusion injury.
      FASEB J. 2007, 21, 2863-2873.
    • Stéphane Massip, Jean Guillon, Pascal Sonnet, Jean-Michel Léger, Jean-Jacques Bosc, Christa E. Müller, Christian Jarry;
      The reactivity of related 6-amino- and 5,6-diaminouracils derived from 2-amino-5-(phenoxymethyl)-2-oxazoline: efficient access to bicyclic pyrimidine derivatives.
      Synthesis 2007, 14, 2193-2197.
    • Dirk Bokemeyer, Darius Panek, Masashi Kitahara, James M. Trzaskos, Christa E. Müller, Jörg Hockemeyer, Uta Kunter, Peter Boor, Jürgen Floege, Herbert J. Kramer, Tammo Ostendorf;
      The map kinase ERK regulates renal activity of cyclin dependent kinase 2 in experimental glomerulonephritis.
      Nephrol. Dial. Transplant 2007, 22, 3431-3441.
    • Andrew M. Farrar, Mariana Pereira, Francisco Velasco, Jörg Hockemeyer, Christa E. Müller;
      Adenosine A2A receptor antagonism reverses the effects of dopamine receptor antagonism on instrumental output and effort-related choice in the rat: implications for studies of psychomotor slowing.
      Psychopharmacology 2007, 191, 579-586.
    • Younis Baqi, Christa E. Müller;
      Catalyst-free microwave-assisted amination of 2-chloro-5-nitrobenzoic acid.
      J. Org. Chem. 2007, 72, 5908-5911.
    • Anna Drabczyńska, Christa E. Müller, Janina Karolak-Wojciechowska, Britta Schumacher, Anke Schiedel, Olga Yuzlenko, Katarzyna Kieć-Kononowicz;
      N9-Benzyl-substituted 1,3-dimethyl- and 1,3-dipropyl-pyrimido[2,1-f]purinediones: synthesis and structure-activity relationships at adenosine A1 and A2A receptors.
      Bioorg. Med. Chem. 2007, 15, 5003-5017.
    • Anna Drabczyńska, Christa E. Müller, Anke Schiedel, Britta Schumacher, Janina Karolak-Wojciechowska, Andrzej Fruziński, Weronika Zobnina, Olga Yuzlenko, Katarzyna Kieć-Kononowicz;
      Phenylethyl-substituted pyrimido[2,1-f]purinediones and related compounds: Structure–activity relationships as adenosine A1 and A2A receptor ligands.
      Bioorg. Med. Chem. 2007, 15, 6956-6974.
    • Paulina Carriba, Oskar Ortiz, Kshitij Patkar, Zuzana Justinova, Jessica Stroik, Andrea Themann, Christa E. Müller, Anima S. Woods, Bruce T. Hope, Francisco Ciruela, Vicent Casadó, Enric I. Canela, Carmen Lluis, Steven R. Goldberg, Rosario Moratalla, Rafael Franco, Sergi Ferré;
      Striatal adenosine A2A and cannabinoid CB1 receptors form functional heteromeric complexes that mediate the motor effects of cannabinoids.
      Neuropsychopharmacology 2007, 32, 2249-2259.
    • Keita Ishiwari, Lisa J. Madson, Andrew M. Farrar, Susana M. Mingote, John P. Valenta, Michael D. DiGianvittorio, Lauren E. Frank, Merce Correa, Jörg Hockemeyer, Christa E. Müller, John D. Salamone;
      Injections of the selective adenosine A2A antagonist MSX-3 into the nucleus accumbens core attenuate the locomotor suppression induced by haloperidol in rats.
      Behavioural Brain Res 2007, 178, 190-199.
    • Elisabetta Coppi, Anna Maria Pugliese, Holger Stephan, Christa E. Müller, Felicita Pedata;
      Role of P2 purinergic receptors on synaptic transmission under normoxic and ischaemic conditions in the CA1 of rat hippocampal slices.
      Purinergic Signal. 2007, 3, 203-219.
    • Anke C. Schiedel, Heiko Meyer, Bernt B. A. Alsdorf, Simone Gorzalka, Hannelore Brüssel, Christa E. Müller;
      [3H]Adenine is a suitable radioligand for the labeling of G protein-coupled adenine receptors but shows high affinity to bacterial contaminations in buffer solutions.
      Purinergic Signal. 2007, 3, 347-358.
    • David Köhler, Tobias Eckle, Marion Faiglem, Almut Grenz, Michel Mittelbronn, Stefanie Laucher, Melanie L. Hart, Simon C. Robinson, Christa E. Müller, Holger K. Eltzschig;
      CD39/Ectonucleoside triphosphate diphosphohydrolase 1 provides myocardial protection during cardia ischemia/reperfusion injury.
      Circulation 2007, 116, 1784-1794.

    2006

    • Joachim C. Burbiel, Jörg Hockemeyer, Christa E. Müller;
      Synthesis of xanthine derivatives by microwave-assisted ring closure reaction.

      ARKIVOC 2006, 77-82.
    • Andreas Brunschweiger, Christa E. Müller;
      P2 Receptors activated by uracil nucleotides – an update.
      Curr. Med. Chem. 2006, 13, 289-312.
    • Stéphane Massip, Jean Guillon, Daniela Bertarelli, Jean-Jacques Bosc, Jean-Michel Léger, Svenja Lacher, Cécile Bontemps, Thibaut Dupont, Christa E. Müller, Christian Jarry;
      Synthesis and preliminary evaluation of new 1- and 3-[1-(2-hydroxy-3-phenoxypropyl)xanthines from 2-amino-2-oxazolines as potential A1 and A2A adenosine receptor antagonists.
      Bioorg. Med. Chem. 2006, 14, 2697-2719.
    • Jacek Bulicz, Daniela C. G. Bertarelli, Dieter Baumert, Friederike Fülle, Christa. E. Müller, Dieter Heber;
      Synthesis and pharmacology of pyrido[2,3-d]pyrimidinediones bearing polar substituents as adenosine receptor antagonists.
      Bioorg. Med. Chem. 2006, 14, 2837-2849.
    • Jamshed Iqbal, Joachim C. Burbiel, Christa E. Müller;
      Development of off-line and on-line capillary electrophoresis method for the screening and characterization of adenosine kinase inhibitors and substrates.

      Electrophoresis 2006, 27, 2505-2517.
    • Andreas Brunschweiger, Christa E. Müller;
      Medizinische Chemie der Diuretika.
      Pharm. Unserer Zeit 2006, 4, 310-320.
    • Luo Yan, Daniela C. G. Bertarelli, Alaa M. Hayallah, Heiko Meyer, Karl-Norbert Klotz, Christa E. Müller;
      A new synthesis of sulfonamides by aminolysis of p-nitrophenylsulfonates yielding potent and selective adenosine A2B receptor antagonists.
      J. Med. Chem. 2006, 49, 4384-4391.
    • Daniela C. G. Bertarelli, Martina Diekmann, Alaa M. Hayallah, Dorothee Rüsing, Jamshed Iqbal, Birgit Preiss, Eugen J. Verspohl, Christa E. Müller;
      Characerization of human and rodent native and recombinant adenosine A2B receptors by radioligand binding studies.
      Purinergic Signal. 2006, 2, 559-571.
    • Stefanie Weyler, Friederike Fülle, Martina Diekmann, Britta Schumacher, Sonja Hinz, Karl-Norbert Klotz, Christa E. Müller;
      Improving potency, selectivity, and water solubility of adenosine A1 receptor antagonists: xanthines modified at position 3 and related pyrimido[1,2,3-cd]purinediones.
      ChemMedChem. 2006, 1, 891-902.
    • Rhalid Akkari, Joachim Burbiel, Jörg Hockemeyer, Christa E. Müller;
      Recent progress in the development of adenosine receptor ligands as antiinflammatory drugs.
      Curr. Top. Med. Chem. 2006, 6, 1375-1399.
    • Christa E. Müller, Jamshed Iqbal, Younis Baqi, Herbert Zimmermann, Anita Röllich, Holger Stephan;
      Polyoxometalates – a new class of potent ecto-nucleoside triphosphate diphosphohydrolase (NTPDase) inhibitors.
      Bioorg. Med. Chem. Lett. 2006, 16, 5943-5947.
    • Małgorzata Filip, Małgorzata Frankowska, Magdalena Zaniewska, Edmund Przegaliński, Christa E. Müller, Luigi F. Agnati, Rafael Franco, David C. S. Roberts, Kjell Fuxe;
      Involvement of adenosine A2A and dopamine receptors in the locomotor and sensitizing effects of cocaine.
      Brain Res. 2006, 1077, 67-80.
    • Ali El-Tayeb, Aidong Qi, Christa E. Müller;
      Synthesis and Structure-Activity Relationships of Uracil Nucleotide Derivatives and Analogues as Agonists of Human P2Y2, P2Y4, and P2Y6 Receptors.
      J. Med. Chem. 2006, 49, 7076-7087.
    • Christa. E. Müller, Jamshed Iqbal, Younis Baqi;
      Kapillarelektrophorese-Nano-Assays in der Wirkstofftestung – Neue In-vitro-Screening-Verfahren auf der Suche nach Arzneistoffen in der Zukunft.
      GIT Labor-Fachzeitschrift 2006, 10, 897-900.
    • Christa E. Müller, Jamshed Iqbal, Younis Baqi;
      Capillary electrophoresis nano-assays - novel in vitro screening methods for future drugs.
      Screening 2006, 4, 26-28.
    • Dorothee Rüsing, Christa E. Müller, Eugen J. Verspohl;
      The impact of adenosine and A2B receptors on glucose homoeostasis.
      J. Pharm. Pharmacol. 2006, 58, 1639-1645.
    • Joachim C. Burbiel, Jörg Hockemeyer, Christa E. Müller;
      Microwave-assisted ring closure reactions: Synthesis of 8-substituted xanthine derivatives and related pyrimido- and diazepinopurinediones.
      Beilstein J. Org. Chem. 2006, 2, No. 20.
    • Anna Drabczyńska, Christa E. Müller, Svenja K. Lacher, Britta Schumacher, Janina Karolak-Wojciechowska, Antony Nasal, Piotr Kawczak, Olga Yuzlenko, Elżbieta Pękala, Katarzyna Kieć-Kononowicz;
      Synthesis and biological activity of tricyclic aryloimidazo-, pyrimido-, and diazepinopurinediones.
      Bioorg. Med. Chem. 2006, 14, 7258-7281.
    • H. Phuoc Le, Christa E. Müller;
      Rapid microwave-assisted fluorourination yielding novel 5’-deoxy-5’-fluoridine derivatives.
      Bioorg. Med. Chem. Lett. 2006, 16, 6139-6142.

    2005 

    • Kerstin Grießmeier, Christa E. Müller;
      [3H]BQ-123 binding to native endothelin ETa receptors in human astrocytoma 1321N1 cells and screening of potential ligands.
      Pharmacology 2005, 74, 51-56.

    • Simone Gorzalka, Sauro Vittori, Rosaria Volpini, Gloria Cristalli, Ivar von Kügelgen, Christa E. Müller;
      Evidence for the functional expression and pharmacological characterization of adenine receptors in native cells and tissues.
      Mol. Pharmacol. 2005, 67, 955-964.
    • Janez Ilas, Slavko Pekar, Jörg Hockemeyer, Harald Euler, Armin Kirfel, Christa E. Müller;
      Development of spin-labeled probes for adenosine receptors.
      J. Med. Chem. 2005, 48, 2108-2114.
    • Marcello Solinas, Sergi Ferré, Katerina Antoniou, Davide Quarta, Zuzana Justinova, Jörg Hockemeyer, L. A. Pappas, P. N. Segal, C. Wertheim, Christa E. Müller, Steven R. Goldberg;
      Involvement of adenosine A1 receptors in the discriminative-stimulus effects of caffeine in rats.
      Psychopharmacology 2005, 179, 576-586.
    • Bernd Kammerer, Antje Frickenschmidt, Christa E. Müller, Stefan Laufer, Christoph H. Gleiter, Hartmut Liebich;
      Mass spectrometric identification of modified urinary nucleosides used as potential biomedical markers by LC-ITMS coupling.
      Anal. Bioanal. Chem. 2005, 382, 1017-1026.
    • Ali El-Tayeb, Kerstin J. Griessmeier, Christa E. Müller;
      Synthesis and preliminary evaluation of [3H]PSB-0413, a selective antagonist radioligand for platelet P2Y12 receptors.
      Bioorg. & Med. Chem. Lett. 2005, 15, 5450-5452.
    • Jamshed Iqbal, Petra Vollmayer, Norbert Braun, Herbert Zimmermann, Christa E. Müller;
      A capillary electrophoresis method for the characterization of ecto-nucleoside triphosphate diphosphohydrolases (NTPDases) and the analysis of inhibitors by in-capillary enzymatic microreaction.
      Purinergic Signal. 2005, 1, 349-358.
    • Charles W. Schindler, Marzena Karcz-Kubicha, Eric B. Thorndike, Christa E. Müller, Srihari R. Tella, Sergi Ferré, Steven R. Goldberg;
      Role of central and peripheral adenosine receptors in the cardiovascular responses to intraperitoneal injections of adenosine A1 and A2A subtype receptor agonists.
      Br. J. Pharmacol. 2005, 144, 642-650.
    • Katerina Antoniou, Z. Papadopoulou-Daifoti, T. Hyphantis, G. Papathanasiou, E. Bekris, M. Marselos, L. Panlilio, Christa E. Müller, Steven R. Goldberg, Sergi Ferré;
      A detailed behavioral analysis of the acute motor effects of caffeine in the rat: involvement of adenosine A1 and A2A receptors.
      Psychopharmacology 2005, 183, 154-162.

    2004

    • Osama M. Abo-Salem, Alaa M. Hayallah, Andras Bilkei-Gorzo, Barbara Filipek, Andreas Zimmer, Christa E. Müller;
      Antinociceptive effects of novel A2B adenosine receptor antagonists.
      J. Pharmacol. Exp. Ther. 2004, 308, 358-366.
    • Luo Yan, Christa E. Müller;
      Preparation, properties, reactions, and adenosine receptor affinities of sulfophenylxanthine nitrophenyl esters: toward the development of sulfonic acid prodrugs with peroral bioavailability.
      J. Med. Chem. 2004, 47, 1031-1043.
    • Katarzyna Kieć-Kononowicz, Janina Karolak-Wojciechowska, Barbara Michalak, Elzbieta Pękala, Britta Schumacher, Christa E. Müller;
      Imidazo[2,1-b]thiazepines: synthesis, structure and evaluation of benzodiazepine receptor binding.
      Eur. J. Med. Chem. 2004, 39, 205-218.
    • Charles W. Schindler, Marzena Karcz-Kubicha, Eric B. Thorndike, Christa E. Müller, Srihari R. Tella, Steven R. Goldberg, Sergi Ferré;
      Lack of adenosine A1 and dopamine D2 receptor-mediated modulation of the cardiovascular effects of the adenosine A2A receptor agonist CGS 21680.
      Eur. J. Pharmacol. 2004, 484, 269-275.
    • Stefan Kehraus, Simone Gorzalka, Christian Hallmen, Jamshed Iqbal, Christa E. Müller, Anthony D. Wright, Michael Wiese, Gabriele M. König;
      Novel amino acid derived natural products from the Ascidian Atriolum robustum: Identification and pharmacological characterization of a unique adenosine derivative.
      J. Med. Chem. 2004, 47, 2243 - 2245.
    • Jörg Hockemeyer, Joachim C. Burbiel, Christa E. Müller;
      Multigram-scale syntheses, stability, and photoreactions of A2A adenosine receptor antagonists with 8-styrylxanthine structure - potential drugs for Parkinson's disease.
      J. Org. Chem. 2004, 69, 3308-3318.
    • Anna Drabczyńska, Christa E. Müller, Britta Schumacher, Sonja Hinz, Janina Karolak-Wojciechowska, Barbara Michalak, Elzbieta Pękala, Katarzyna Kieć-Kononowicz;
      Tricyclic oxazolo[2,3-f]purinediones: Potency as adenosine receptor ligands and anticonvulsants.
      Bioorg. Med. Chem. 2004, 12, 4895-4908.
    • Christa E. Müller;
      Diuretika – Neue Errungenschaften.
      Pharm. Ztg. 2004, 149, 16-22.

    2003

    • Stefanie Weyler, Alaa M. Hayallah, Christa E. Müller;
      Versatile, convenient synthesis of pyrimido[1,2,3-cd]purinediones.
      Tetrahedron 2003, 59, 47-54.
    • Zhan-Guo Gao, Neli Melman, Andreas Erdmann, Seong Gon Kim, Christa E. Müller, Adriaan P. IJzerman, Kenneth A. Jacobson;
      Differential allosteric modulation by amiloride analogues of agonist and antagonist binding at A1 and A3 Adenosine Receptors.
      Biochem. Pharmacol. 2003, 65, 525-534.
    • Christa E. Müller;
      Medicinal chemistry of adenosine A3 receptor ligands.
      Curr. Top. Med. Chem. 2003, 3, 445-462.
    • Vita Ozola, Mark Thorand, Martina Diekmann, Ramatullah Qurishi, Britta Schumacher, Kenneth A. Jacobson, Christa E. Müller;
      2-Phenylimidazo[2,1-i]purin-5-ones: structure-activity relationships and characterization of potent and selective inverse agonists at human A3 adenosine receptors.
      Bioorg. Med. Chem. 2003, 11, 347-356.
    • Omeran Fihd, Maciej Pawłowski, Sławomir Jurczyk, Christa E. Müller, Britta Schumacher;
      Pyrimidin-8-on[2,1-f]theophylline-9-alkylcarboxylic acids amides as A1 and A2A adenosine receptor ligands.
      Il Farmaco 2003, 58, 439-444.
       
    • Marko Kaulich, Ramatullah Qurishi, Christa E. Müller;
      Extracellular metabolism of nucleotides in neuroblastoma x glioma NG108-15 cells determined by capillary electrophoresis.

      Cell. Mol. Neurobiol. 2003, 23, 349-364.
    • Marko Kaulich, Franziska Streicher, Ralf Mayer, Ingrid Müller, Christa E. Müller;
      Flavonoids – novel lead compounds for the development of P2Y2 receptor antagonists.
      Drug Dev. Res. 2003, 59, 72-81.
    • Anna Drabczyńska, Britta Schumacher, Christa E. Müller, Janina Karolak-Wojciechowska, Barbara Michalak, Elżbieta Pękala, Katarzyna Kieć-Kononowicz;
      Impact of the aryl substituent kind and distance from pyrimido[2,1-f]purindiones on the adenosine receptor selectivity and antagonistic properties.
      Eur. J. Med. Chem. 2003, 38, 397-402.
    • David Blum, Marie-Christine Galas, Annita Pintor, Emmanuel Brouillet, Catherine Ledent, Christa E. Müller, Kadiombo Bantubungi, Mariangela Galluzzo, David Gall, Laetitia Cuvelier, Anne-Sophie Rolland, Patrizia Popoli, Serge N. Schiffmann;
      A dual role of adenosine A2A receptors in the modulation of 3-nitropropionic acid-induced striatal lesions: implications for the neuroprotective potential of A2A antagonists.
      J. Neurosci. 2003, 23, 5361-5369.
    • Joachim Burbiel, Mark Thorand, Christa E. Müller;
      Improved, efficient synthesis for multigram-scale production of PSB-10, a potent antagonists at human A3 adenosine receptors.
      Heterocycles 2003, 60, 1425-1432.
    • Jens Nagel, Henning Schladebach, M. Koch, Isabel Schwienbacher, Christa E. Müller, Wolfgang Hauber;
      Effects of an adenosine A2A receptor blockade in the nucleus accumbens on locomotion, feeding, and prepulse inhibition in rats.
      Synapse 2003, 49, 279-286.
    • Luo Yan, Joachim C. Burbiel, Astrid Maaß, Christa E. Müller;
      Adenosine receptor agonists: from basic medicinal chemistry to clinical development.
      Expert Opin. Emerging Drugs 2003, 8, 537-576.
    • Marzena Karcz-Kubicha, Katerina Antoniou, Anton Terasmaa, Davide Quarta, Marcello Solinas, Zuzana Justinova, Antonella Pezzola, Rosaria Reggio, Christa E. Müller, Kjell Fuxe, Steven R. Goldberg, Patrizia Popoli, Sergi Ferré;
      Involvement of adenosine A1 and A2A receptors in the motor effects of caffeine after its acute and chronic administration.
      Neuropsychopharmacol. 2003, 28, 1281-1291.
    • Marzena Karcz-Kubicha, Davide Quarta, Bruce T. Hope, Katerina Antoniou, Christa E. Müller, Marisela Morales, Charles W. Schindler, Steven R. Goldberg, Sergi Ferré;
      Enabling role of adenosine A1 receptors in adenosine A2A receptor-mediated striatal expression of c-fos.
      Eur. J. Neurosci. 2003, 18, 296-302.
    • H. Euler, Armin Kirfel, Alexander Bauer, Christa E. Müller;
      Crystal structure of 9-benzyl-6-ethoxy-7-ethyl-2-phenyl-7,9-dihydropurin-8-one, C22H22N4O2.
      Z. Kristallogr. NCS 2003, 218, 473-474.

    2002

    • Christa E. Müller, Martina Diekmann, Mark Thorand, Vita Ozola;
      [3H]8-Ethyl-4-methyl-2-phenyl-(8R)-4,5,7,8-tetrahydro-1H-imidazo[2,1-i]purin-5-one ([3H]PSB-11), a novel high-affinity antagonist radioligand for human A3 adenosine receptors.
      Bioorg. Med. Chem. Lett. 2002, 12, 501-503.
    • Alaa M. Hayallah, Jesús Sandoval-Ramírez, Ulrike Reith, Ulrike Schobert, Birgit Preiss, Britta Schumacher, John W. Daly, Christa E. Müller;
      1,8-Disubstituted xanthine derivatives: synthesis of potent A2B-selective adenosine receptor antagonists.
      J. Med. Chem. 2002, 45, 1500-1510.
    • Ramatullah Qurishi, Marko Kaulich, Christa E. Müller;
      Fast, efficient capillary electrophoresis method for measuring nucleotide degradation and Metabolism.
      J. Chromatogr. A 2002, 952, 275-281.
    • Karl Vollmann, Christa E. Müller;
      Synthesis of 8-substituted xanthine derivatives by Suzuki cross-coupling reaction.
      Heterocycles 2002, 57, 871-879.
    • Soon-Ai Kim, Melissa A. Marshall, Neli Melman, Hak Sun Kim, Christa E. Müller, Joel Linden, Kenneth A. Jacobson;
      Structure-activity relationships at human and rat A2B adenosine receptors of xanthine derivatives substituted at the 1-, 3-, 7-, and 8-positions.
      J. Med. Chem. 2002, 45, 2131-2138.
    • Christa E. Müller, Mark Thorand, Ramatullah Qurishi, Martina Dieckmann, Kenneth A. Jacobson, William L. Padgett, John W. Daly;
      Imidazo[2,1-i]purin-5-ones and related tricyclic water-soluble purine derivatives: potent A2A- and A3-adenosine receptor antagonists.
      J. Med. Chem. 2002, 45, 3440-3450.
    • Zaida Díaz-Cabiale, Meritxell Vivó, Alberto del Arco, William T. O'Connor, Michael K. Harte, Christa E. Müller, Emili Martínez, Patrizia Popoli, Kjell Fuxe, Sergi Ferré;
      Metabotropic glutamate mGlu5 receptor-mediated modulation of the ventral striatopallidal GABA pathway in rats. Interactions with adenosine A2A and dopamine D2 receptors.
      Neurosci. Lett. 2002, 324, 154-158.
    • Christa E. Müller, Britta Schumacher, Axel Brattström, Ehab A. Abourashed, Uwe Koetter;
      Interactions of valerian extracts and a fixed valerian-hop extract combination with adenosine receptors.
      Life Sci. 2002, 71, 1939-1949.
    • Zhan-Guo Gao, Aishe Chen, Dov Barak, Soo-kyung Kim, Christa E. Müller, Kenneth A. Jacobson;
      Identification by site-directed mutagenesis of residues involved in ligand recognition and activation of the human A3 adenosine receptor.
      J. Biol. Chem. 2002, 277, 19056-19063.
    • Christa E. Müller;
      P2-Pyrimidinergic receptors and their ligands.

      Curr. Pharm. Des. 2002, 8, 2353-2370.
    • Christa E. Müller, Marcus A. Hubert, Ralf Mayer;
      Parkinson-Therapeutika. Teil I: Etablierte, neue und zukünftige Arzneistoffe – Struktur und Wirkungsmechanismen.
      Dtsch. Apoth. Ztg. 2002, 142, 4569-4579.
    • Marcus A. Hubert, Ralf Mayer, Christa E. Müller;
      Parkinson-Therapeutika. Teil II: Wirkstoff-Dossiers, Therapiekonzepte und pharmazeutische Betreuung.
      Dtsch. Apoth. Ztg. 2002, 142, 4708-4717.
    • Katarzyna Kieć-Kononowicz, Christa E. Müller, Elzbieta Pękala, Janina Karolak-Wojciechowska, J. Handzlik, D. Łażewska;
      Imidazo[2,1-b]thiazoles, imidazo[2,1-b]imidazoles, and pyrrolo[1,2-c]imidazoles. Synthesis, structure and evaluation of benzodiazepine receptor binding.
      J. Heterocyclic Chem. 2002, 38, 243-253.
    • Britta Schumacher, Silke Scholle, Josef Hölzl, Nasser Khudeir, Sonja Hess, Christa E. Müller;
      Lignans isolated from valerian: identification and characterization of a new olivil derivative with partial agonistic activity at A1 adenosine receptors.
      J. Nat. Prod. 2002, 65, 1479-1485.
    • H. Euler, Armin Kirfel, Sven Jan Freudenthal, Christa E. Müller;
      Crystal structure of 4-bromobutyric acid 3-((4,4-difluoro-1,3,5,7-tetramethyl-4-bora-3a,4a-diaza-s-indacen)-8-yl)propyl ester, C20H26BBrF2N2O2.
      Z. Kristallogr. NCS 2002, 217, 541-542.
    • H. Euler, Armin Kirfel, Sven Jan Freudenthal, Christa E. Müller;
      Crystal structure of 8-(5-bromopentyl)-4,4-difluoro-1,3,5,7-tetramethyl-4-bora-3a,4a-diaza-s-indacene, C18H24BBrF2N2.
      Z. Kristallogr. NCS 2002, 217, 543-545.

    2001

    • Christa E. Müller;
      A1 Adenosine receptors and their ligands: overview and recent developments.
      Il Farmaco 2001, 56, 77-80.
    • Sergi Ferré, Patrizia Popoli, L. Giménez-Llort, R. Rimondini, Christa E. Müller, Ingrid Strömberg, Sven O. Ögren, Kjell Fuxe;
      Adenosine/dopamine interaction: implication for the treatment of Parkinson's disease.
      Parkinsonism and Related Disorders 2001, 7, 235-241.
    • Katarzyna Kieć-Kononowicz, Janina Karolak-Wojciechowska, Christa E. Müller, Britta Schumacher, Elżbieta Pękala, Ewa Szymanska;
      Imidazothiazine, -diazinone and -diazepinone derivatives. Synthesis, structure and benzodiazepine receptor binding.
      Eur. J. Med. Chem.
      , 2001, 36, 407-419.
    • Christa E. Müller;
      A3 Adenosine receptor antagonists;
      Mini-Rev. Med. Chem. 2001, 1, 417-427.
    • Wolfgang Hauber, Patric Neuscheler, Jens Nagel, Christa E. Müller;
      Catalepsy induced by a blockade of dopamine D1 or D2 receptors was reversed by a concomitant blockade of A2A receptors in the caudate-putamen of rats.
      Eur. J. Neurosci. 2001, 14, 1287-1293.
    • Zhan-Guo Gao, Jacqueline E. van Muijlwijk-Koezen, Aishe Chen, Christa E. Müller, Adriaan P. IJzerman, Kenneth A. Jacobson;
      Allosteric modulation of A3 adenosine receptors by a series of 3-(2-pyridinyl)­isoquinoline derivatives.
      Mol. Pharmacol. 2001, 60, 1057-1063.
    • Katarzyna Kieć-Kononowicz, A. Drabczyńska, Elzbieta Pękala, B. Michalak, Christa E. Müller, Britta Schumacher, Janina Karolak-Wojciechowska, H. Duddeck, S. Rockitt, R. Wartchow;
      New developments in A1 and A2 adenosine receptor antagonists.
      Pure Appl. Chem. 2001, 73, 1411-1420.

    2000

    • Roland Sauer, Juris Maurinsh, Ulrike Reith, Friederike Fülle, Karl-Norbert Klotz, Christa E. Müller;
      Water-soluble phosphate prodrugs of 1-propargyl-8-styrylxanthine derivatives, A2A-selective adenosine receptor antagonists.
      J. Med. Chem. 2000, 43, 440-448.
    • Friederike Fülle, Christa E. Müller;
      A novel ring closure reaction for the preparation of 6-aminouracils with an a-branched 1-substituent.
      Heterocycles, 2000, 53, 347-351.
    • Christa E. Müller, Juris Maurinsh, Roland Sauer;
      Binding of [3H]MSX-2 (3-(3-hydroxypropyl)-7-methyl-8-(m-methoxystyryl)-1-propargylxanthine) to rat striatal membranes - a new, selective antagonist radioligand for A2A adenosine receptors.
      Eur. J. Pharm. Sci. 2000, 10, 259-265.
    • Antje Harms, Daniela Gündisch, Christa E. Müller, Karl-Artur Kovar;
      Development of a 5-hydroxytryptamine 5-HT2A receptor binding assay for high throughput screening using 96-Well microfilter plates.
      J. Biomol. Screening 2000, 5, 269-277.
    • Ingrid Strömberg, Patrizia Popoli, Christa E. Müller, Sergi Ferré, Kjell Fuxe;
      Electrophysiological and behavioral evidence for an antagonistic modulatory role of adenosine A2A receptors in dopamine D2 receptor regulation in the rat dopamine denervated striatum.
      Eur. J. Neurosci. 2000, 12, 4033-4037.
    • Sonja Hess, Christa E. Müller, Wolfram Frobenius, Ulrike Reith, Karl-Norbert Klotz, Kurt Eger
      7-deazaadenines bearing polar substituents: structure-activity relationships of new A1 and A3 adenosine receptor antagonists.
      J. Med. Chem. 2000, 43, 4636-4646.
    • Christa E. Müller;
      Adenosine receptor ligands – recent developments. Part I. Agonists.
      Curr. Med. Chem. 2000, 7, 1269-1288.
    • Christa E. Müller;
      A2A Adenosine receptor antagonists – future drugs for Parkinson's disease?
      Drugs of the Future, 2000, 25, 1043-1052.

    1998 – 1999

    • Christa E. Müller;
      Xanthine - Renaissance einer altbekannten Naturstoffklasse.
      In: Pichler, H. (Hrsg.) Zwischen Wissenschaft und Kunst. Hermann Josef Roth - Portrait eines nicht nur wissenschaftlichen Lebens. ISBN: 978-3-7692-2212-8
      Deutscher Apotheker Verlag, Stuttgart 1998, S. 73-88.
    • Armin Kirfel, F. Schwabenländer, Christa E. Müller;
      Crystal structure of 6-amino-3-methyl-5-nitrosopyrimidine-2,4(1H,3H)-dione monosodium dihydrate, C5H5N4O3Na 2H2O;
      Z. Kristallogr. NCS 1998, 213, 141-142.
    • Bernd H. A. Knoblauch, U. Köster, Christa E. Müller, F. Möller;
      Crystal structure of 5-ethyl-1-(2',3',5'-tri-O-benzoyl-b-D-ribofuranosyl)-2,4(3H)-
      pyrimidinedione, C32H28N2O9
      Z. Kristallogr. NCS 1998, 213, 143-144.
    • Bernd H. A. Knoblauch, U. Köster, Christa E. Müller, F. Möller;
      Crystal structure of 6-amino-3-(2',3',5'-tri-O-benzoyl-b-D-ribofuranosyl)-2,4(1H)-pyrimidinedione, C31H29N3O10
      Z. Kristallogr. NCS 1998, 213, 145-146.
       
    • Claudia Eder, Peter Schupp, Peter Proksch, Victor Wray, Klaus Steube, Christa E. Müller, Wolfram Frobenius, Markus Herderich, Rob W. M. van Soest;
      Bioactive pyridoacridine alkaloids from the Micronesian sponge Oceanapia sp.
      J. Nat. Prod. 1998, 61, 301-305.
    • Hermann J. Roth, Christa E. Müller, Gerd Folkers;
      Stereochemie & Arzneistoffe. Grundlagen - Betrachtungen - Auswirkungen. (Lehrbuch)
      Wissenschaftliche Verlagsgesellschaft Stuttgart 1998 (ISBN 3-8047-1485-4).
    • Wolfgang Hauber, Jens Nagel, Roland Sauer, Christa E. Müller;
      Motor effects induced by a blockade of adenosine A2A receptors in the caudate-putamen.
      Neuroreport 1998, 9, 1803-1806.
    • Christa E. Müller, Jesús Sandoval-Ramírez, Ulrike Schobert, Uli Geis, Wolfram Frobenius, Karl-Norbert Klotz;
      8-(Sulfostyryl)xanthines: water-soluble A2A-selective adenosine receptor antagonists.
      Bioorg. Med. Chem. 1998, 6, 707-719.
    • Barbara Matuszczak, Elsbieta Pekala, Christa E. Müller;
      1-Substituted 4-[chloropyrazolyl][1,2,4]triazolo[4,3-a]quinoxalines: synthesis and structure-activity relationships of a new class of benzodiazepine and adenosine receptor ligands.
      Arch. Pharm. Pharm. Med. Chem. 1998, 331, 163-169.
    • Christa E. Müller, Dirk Deters, Andreas Dominik;
      Syntheses of paraxanthine and isoparaxanthine analogs (1,7- and 1,9-Substituted Xanthine Derivatives).
      Synthesis 1998, 1428-1436.
    • Christa E. Müller, Ingrid Müller;
      Neue Migräne-Therapeutika im Überblick.
      Pharm. Unserer Zeit, 1998, 27, 209-215.
    • Christa E. Müller, Roland Sauer, Yuris Maurinsh, Rosa Huertas, Friederike Fülle, Karl-Norbert Klotz, Jens Nagel, Wolfgang Hauber;
      A2A-Selective adenosine receptor antagonists: development of water-soluble prodrugs and a new tritiated radioligand.
      Drug Dev. Res. 1998, 45, 190-197
    • Katarzyna Kieć-Kononowicz, Janina Karolak-Wojciechowska, Christa E. Müller, Uli Geis, Waldemar Ksiazek, Ewa Szymanska;
      Arylidene imidazothiazoles. Synthesis, structure and benzodiazepine receptor binding.
      J. Heterocyclic Chemistry 1998, 36, 257-263.
    • Christa E. Müller;
      Basic chemistry of 2-nitroimidazoles (azomycin derivatives).
      In: Machulla, H.-J. (Hrsg.), Hypoxia Imaging. Kluwer Academic Publishers, Dordrecht, Boston, London, 1999.
    • Bernd H. A. Knoblauch, Christa E. Müller, Leif Järlebark, Grace Lawoko, Thomas Kottke, Martin A. Wikström, Edith Heilbronn;
      5-Substituted UTP derivatives as P2Y2 receptor agonists.
      Eur. J. Med. Chem. 1999, 34, 809-824.

     1994 – 1997

    • Christa E. Müller;
      Formation of 7,9-disubstituted xanthinium compounds under mild conditions by alkylation of silylated xanthines.
      Synth. Commun. 1994, 24, 1311-1315.
    • Christa E. Müller;
      Barbitursäurederivate und verwandte Stoffe.
      Hager's Handbuch der Pharmazeutischen Praxis, 5. Auflage,
      v. Bruchhausen, G. Dannhardt, S. Ebel, A. W. Frahm, E. Hackenthal und U. Holzgrabe (Hrsg.); Bände 8 und 9: Stoffe, 26 Monographien; Springer Verlag Heidelberg,
      1994.
    • Christa E. Müller;
      Formation of oxazolo[3,2-a]purinones from propynyluracils.
      J. Org. Chem. 1994, 59, 1928-1929.
    • Bettina Grahner, Susanne Winiwarter, Wolfgang Lanzner, Christa E. Müller;
      Synthesis and structure-activity relationships of deazaxanthines - analogs of potent A1- and A2-adenosine receptor antagonists.
      J. Med. Chem. 1994, 37, 1526-1534.
    • Christa E. Müller, Bettina Grahner, Dieter Heber;
      Amino-substituted 1,8-naphthyridines and pyrido[2,3-d]pyrimidines: new compounds with affinity for A1- and A2-adenosine receptors.
      Pharmazie 1994, 49, 878-880.
    • Uli Geis, Bettina Grahner, Maciej Pawłowski, Anna Drabczynska, Maria Gorczyca, Christa E. Müller;
      Tricyclic theophylline derivatives with high water-solubility: structure-activity relationships at adenosine receptors, phosphodiesterases and benzodiazepine binding sites.
      Pharmazie 1995, 50, 333-336.
    • Christa E. Müller;
      Nicotin - vom Genußmittel zum Arzneistoff?
      Dtsch. Apoth. Ztg. 1995, 135, 3253-3268.
    • Christa E. Müller, Jesús Sandoval-Ramírez;
      A new versatile synthesis of xanthines with variable substituents in the 1-, 3-, 7-, and 8‑positions.
      Synthesis 1995, 1295-1299.
    • Christa E. Müller;
      Epibatidin - ein nicotinartiges, analgetisch wirksames Alkaloid aus Pfeilgiftfröschen.
      Pharm. Unserer Zeit 1996, 25, 85-92.
    • Christa E. Müller, Uli Geis, Bettina Grahner, Wolfgang Lanzner, Kurt Eger;
      Chiral pyrrolo[2,3-d]pyrimidine and pyrimido[4,5-b]indole derivatives: structure-activity relationships of potent, highly stereoselective A1-adenosine receptor antagonists.
      J. Med. Chem. 1996, 39, 2482-2491.
    • Uli Geis, Katarzyna Kieć-Kononowicz, Christa E. Müller;
      Benzylidine-substituted imidazo-thiazole, -thiazine and -thiazepine derivatives: a new class of ligands for the benzodiazepine binding site of GABAA receptors.
      Sci. Pharm. 1996, 64, 383-390.
    • Christa E. Müller, Birgitt Stein;
      Adenosine receptor antagonists: structures and potential therapeutic applications.
      Curr. Pharm. Des. 1996, 2, 501-530.
    • Christa E. Müller, Roland Sauer, Uli Geis, Wolfram Frobenius, Przemysław Talik, Maciej Pawłowski;
      Aza-analogs of 8-styrylxanthines as A2A-adenosine receptor antagonists.
      Arch. Pharm. Pharm. Med. Chem. 1997, 330, 181-189.
    • Christa E. Müller;
      A1-Adenosine receptor antagonists.
      Exp. Opin. Ther. Patents 1997, 7, 419-440.
    • Edith Heilbronn, Bernd H.A. Knoblauch, Christa E. Müller;
      Uridine nucleotide receptors and their ligands: structural, physiological, and patho­physiological aspects, with special emphasis on the nervous system.
      Neurochem. Res. 1997, 22, 1041-1050.
    • Christa E. Müller, Ulrike Schobert, Jo Hipp, Uli Geis, Wolfram Frobenius, Maciej Pawłowski;
      Configurationally stable analogs of 8-styrylxanthines as A2A-adenosine receptor antagonists.
      Eur. J. Med. Chem. 1997, 32, 709-719.
    • Armin Kirfel, F. Schwabenländer, Christa E. Müller
      Crystal structure of 1-propyl-8-(4-sulfophenyl)-7H-imidazo[4,5-d]pyrimidin-2,6(1H,3H)-dione dihydrate, C14H14N4O5S x 2 H2O
      Z. Kristallographie - New Cryst. Struct. 1997, 3, 447-448.
    • Christa E. Müller, Uli Geis, Jo Hipp, Ulrike Schobert, Wolfram Frobenius, Maciej Pawłowski, Fumio Suzuki, Jesús Sandoval-Ramírez;
      Synthesis and structure-activity relationships of DMPX (3,7-dimethyl-1-propargyl‑xanthine) derivatives, A2A-selective adenosine receptor antagonists.
      J. Med. Chem. 1997, 40, 4396-4405.

    1989 - 1993

    • Gerd Folkers, Gerlinde Junginger, Christa E. Müller, Ulrich Schloz, Kurt Eger;
      Synthese Computergraphik berechneter high-anti-fixierter Pyrimidin-Nucleosid-Analoga mit potentieller virostatischer und antineoplastischer Wirksamkeit.
      Arch. Pharm. (Weinheim) 1989, 322, 119-123.
    • Christa E. Müller, Hermann J. Roth;
      Amphiphile unsymmetrische Disulfide als Liposomenbausteine.
      Arch. Pharm. (Weinheim) 1989, 322, 342-350.
    • Christa E. Müller, Peter T. Daniel, Joachim Holzschuh, Hermann J. Roth;
      Lipophilic disulfide prodrugs - syntheses and disulfide bond cleavage.
      Int. J. Pharm. 1989, 57, 41-47.
    • Peter T. Daniel, Joachim Holzschuh, Christa E. Müller, Hermann J. Roth, Peter A. Berg;
      Inhibition of phytohemagglutinine-induced T lymphocyte proliferation by 6-(octadecyldithio)purine, a novel liposomal prodrug of 6-mercaptopurine.
      Arch. Toxicol. Suppl. 1989, 13, 179-182.
    • Christa E. Müller, Gerd Folkers;
      Adenosinrezeptor-Liganden - Arzneistoffe der Zukunft?
      Pharm. Unserer Zeit 1989, 18, 65-75.
    • Christa E. Müller, Herrmann J. Roth;
      A new synthesis of thiophosphoric acid esters with a C-S-P bond.
      Tetrahedron Lett. 1990, 31, 501-502.
    • Christa E. Müller, Izumi Hide, John W. Daly, Klaus Rothenhäusler, Kurt Eger;
      7-Deaza-2-phenyladenines - structure-activity relationships of potent A1 selective adenosine receptor antagonists.
      J. Med. Chem. 1990, 33, 2822-2828.
    • Hydar Ali, Christa E. Müller, John W. Daly, Michael Beaven;
      Methylxanthines block antigen-induced responses in RBL-2H3 cells independently of adenosine receptors and cyclic AMP: evidence for inhibition of antigen binding to IgE
      J. Pharm. Exp. Therap. 1991, 258, 954-962.
    • John W. Daly, Izumi Hide, Christa E. Müller, Mah Shamim;
      Caffeine analogs: structure-activity relationships at adenosine receptors.
      Pharmacology 1991, 42, 309-321.
    • Christa E. Müller;
      Synthesis of 3-substituted 6-aminouracils.
      Tetrahedron Lett. 1991, 32, 6539-6540.
    • Christa E. Müller;
      Synthesis and properties of 1-monosubstituted xanthines.
      Synthesis 1993, 125-128.
    • Kenneth A. Jacobson, Dan Shi, Carola Gallo-Rodriguez, Malcolm Manning Jr., Christa E. Müller, John W. Daly, John L. Neumeyer, Leonidas Kiriasis, Wolfgang Pfleiderer;
      Effect of trifluoromethyl- and other substituents on activity of xanthines at adenosine receptors.
      J. Med. Chem. 1993, 36, 2639-2644.
    • Christa E. Müller, Tom Scior;
      Adenosine receptors and their modulators.
      Pharm. Acta Helv. 1993, 68, 77-111.
    • Christa E. Müller, Dan Shi, Malcolm Manning Jr., John W. Daly;
      Synthesis of paraxanthine analogs (1,7-disubstituted xanthines) and other xanthines unsubstituted at the 3-position: structure-activity relationships at adenosine receptors.
      J. Med. Chem. 1993, 36, 3341-3349.
    • Christa E. Müller, John W. Daly;
      Stimulation of calcium release by caffeine analogs in pheochromocytoma cells.
      Biochem. Pharmacol. 1993, 46, 1825-1829.

     

     

     

    • Marie-Therese Fuzzati-Armentero, Silvia Cerri, Giovanna Levandis, Giulia Ambrosi, Elena Montepeloso, Gianfilippo Antoninetti, Fabio Blandini, Younis Baqi, Christa E. Müller, Rosario Volpini, Giulia Costa, Nicola Simola, Annalisa Pinna;
      Dual target strategy: combining distinct non-dopaminergic treatments reduces neuronal cell loss and synergistically modulates l-DOPA-induced rotational behavior in a rodent model of Parkinson's disease.
      J. Neurochem. 2015, 134, 740-747.

     

    • Yue Zhang, János Peti-Peterdi, Christa E. Müller, Noel G. Carlson, Younis Baqi, David L. Strasburg, Kristina M. Heiney, Karie Villaneuva, Donald E. Kohan, Bellamkonda K. Kishore;
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      Adenosine A2A receptor antagonists in Drug Development.
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